Effects of different doses of caffeine on energy expenditure, heart rate, blood pressure, and blood lipids in healthy adults

Effect of the use of Caffeine Supplementation in different dosages on resting energy expenditure, heart rate, blood pressure, and lipid profile in healthy individuals

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-4wqfd34

Enrollment

Registered

2026-07-21

Start date

2014-04-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

This is a randomized, double-blind, crossover clinical trial involving 12 healthy adults of both sexes. The participants and the researchers in charge will be blinded regarding the substance used on t

Eligibility

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Participants aged 18 to 35 years; both sexes; absence of clinical conditions; no continuous use of medications such as diuretics, corticosteroids, or beta-blockers; no dietary restrictions (lactose intolerance, gluten allergy, cow's milk protein allergy); non-smokers; physically active

Exclusion criteria

Exclusion criteria: Functional limitation, family history of cardiovascular diseases, use of food supplements (especially thermogenic/slimming supplements), being a regular consumer of coffee (usual intake estimated at up to 100 mg/day), teas and/or soft drinks that contain caffeine in their formulation and consume other stimulant drinks.

Design outcomes

Primary

Measure	Time frame
Outcome found 1: Only the 500 mg caffeine dose elicited an increase in the fat oxidation rate—which began 60 minutes after ingestion and remained elevated until the end of the experiment—compared to the other experimental conditions (p-value = 0.00187). Caffeine supplementation at various doses did not affect hemodynamic variables during the 120-minute period compared to the placebo (p-value > 0.05);Expected outcome 1:Changes in fat oxidation rate (mg/min), blood pressure (mmHg), and serum triglyceride levels (mg/dL) are expected to be identified after the ingestion of different doses of caffeine by comparing the values obtained before and after each intervention	—

Measure

Time frame

Outcome found 1: Only the 500 mg caffeine dose elicited an increase in the fat oxidation rate—which began 60 minutes after ingestion and remained elevated until the end of the experiment—compared to the other experimental conditions (p-value = 0.00187). Caffeine supplementation at various doses did not affect hemodynamic variables during the 120-minute period compared to the placebo (p-value > 0.05);Expected outcome 1:Changes in fat oxidation rate (mg/min), blood pressure (mmHg), and serum triglyceride levels (mg/dL) are expected to be identified after the ingestion of different doses of caffeine by comparing the values obtained before and after each intervention

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Secondary

Measure	Time frame
Expected outcome 2: Changes in the carbohydrate oxidation rate (mg/min) are expected to be identified following the ingestion of different doses of caffeine, comparing values ??obtained before and after each intervention;Outcome found 2: Resting energy expenditure and the carbohydrate oxidation rate were not altered by caffeine supplementation under any of the experimental conditions (P-value > 0.05)	—

Measure

Time frame

Expected outcome 2: Changes in the carbohydrate oxidation rate (mg/min) are expected to be identified following the ingestion of different doses of caffeine, comparing values ??obtained before and after each intervention;Outcome found 2: Resting energy expenditure and the carbohydrate oxidation rate were not altered by caffeine supplementation under any of the experimental conditions (P-value > 0.05)

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Countries

Contacts

Public ContactGiuseppe Stefani

Universidade Federal de Ciências da Saúde de Porto Alegre

giuseppes@ufcspa.edu.br+55(51)3303-8820

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026