1) Genotoxicity 2) Occupational Exposure 3) Diseases of the endocrine system 4) Immune system disorders
Conditions
Interventions
Biomonitoring of the participants by means of venous blood collection.
Experimental group: 23 resident physicians occupationally exposed to the residues of inhalational anesthetics, from the beginning
Sponsors
Departamento de Anestesiologia
Faculade de Medina de Botucatu - UNESP
Eligibility
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Start of medical residency in 2015 in anesthesiology areas; general surgery; orthopedics; neurosurgery; healthy volunteers; both genders; age between 18 and 35 years
Exclusion criteria
Exclusion criteria: Have done medical residence in the areas of interest of the study; Carrier malignancy; be more than 35 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As expected, the potential increase in DNA damage detected by the comet assay, cytotoxicity assessed by flow cytometry, oxidative stress from protein and lipid oxidation markers by immunoassay (ELISA), and biochemical markers for dry and hormonal chemistry by chemiluminescence during the time of occupational exposure of study participants. The tests using all the mentioned markers are in progress and the sample size was calculated based on the MDA (lipid oxidation marker) evaluation, determining 23 individuals, with 95% test power. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactAline Aun
Faculade de Medina de Botucatu - UNESP
Outcome results
None listed