Alzheimers disease
Conditions
Interventions
This is a cross-sectional observacional study and the aim is to evaluate whether the APOE genotype influences the P300 of the elderly in the mild and moderate stages of Alzheimers disease and of the e
Other
D10.532.091.500.750
Sponsors
Universidade Federal de São Carlos
Universidade Federal de São Carlos
Eligibility
Inclusion criteria
Inclusion criteria: Healthy elderly: present preserved cognition as evaluated by the Mini-Mental State Examination. No diagnosis of depression or clinically relevant depressive symptoms assessed through the Geriatric Depression Scale (GDS-30). Elderly people without cognitive impairment and who are able to perform ERP-P300 evaluation. Not have reported any neuropsychiatric disease. Elderly with Alzheimer's disease: Clinical diagnosis of AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Stages between mild and moderate according to the Clinical Dementia Rating (CDR). Elderly who are able to perform ERP-P300 evaluation. Not have reported other neuropsychiatric disease.
Exclusion criteria
Exclusion criteria: Advanced stage of Alzheimer's disease. Do not permormed ERP-P300.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healthy elderly and elderly with ALzheimer's disease who are carriers of the APOE E4 allele present lower amplitude and higher P300 latency than the non-E4 allele carriers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Healthy elderly and elderly with Alzheimer's disease with lower concentration of neurotrophic factors (BDNF, VEGF and IGF-1) show lower amplitude and higher P300 latency than those with higher concentration. | — |
Countries
Brazil
Contacts
Public ContactRenata Pedroso
Universidade Federal de São Carlos
Outcome results
None listed