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Influence of low-doses Dextroketamine on Brain Monitoring

Influence of low-doses Dextroketamine on the rate of Electroencephalogram Suppression

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
REBEC
Registry ID
RBR-4vdpqrt
Enrollment
Unknown
Registered
2023-03-02
Start date
2022-08-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ketamine

Interventions

This is a two-arm, triple-blind, randomized, controlled clinical trial. Twenty adult patients, with ten in each group, both genders, aged between 20 and 50 years, will undergo controlled effector-site

Sponsors

Hospital São Carlos
Lead Sponsor
Hospital São Carlos
Collaborator

Eligibility

Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Volunteers with physical status P1 (American Society of Anesthesiologists); both genders; age between 20 and 50 years; body mass index between 21 and 26kg.m-2

Exclusion criteria

Exclusion criteria: Recent use of drugs that alter the electroencephalogram

Design outcomes

Primary

MeasureTime frame
Expectaded outcome 1: It is expected to find changes in the values of the suppression rate and bispectral index after infusion of low doses of dextroketamine, verified through the processed electroencephalogram, from the observation of a pre- and post-intervention variation with statistical significance of p=0, 05;Finding 1: There were no statistically significant changes regarding supression rate. There was also no indication of a significant difference between the average supression rate values concerning the factors group and moment

Secondary

MeasureTime frame
Secondary outcomes were not expected

Countries

Brazil

Contacts

Public ContactFilipe Akamine

Hospital São Carlos

fih@akamine.com.br+55(85)4009-1278

Outcome results

None listed

Source: REBEC (via WHO ICTRP)