Myocardial infarction
Conditions
Interventions
This is a two-arm, open-masked, randomized clinical trial. Randomization will be met with a randomization table created in excel. Experimental group: 60 volunteers, men and women, adults and elderly,
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G07.203.650.240
Sponsors
Universidade Federal de Alagoas
Universidade Federal de Alagoas
Eligibility
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteers who survived Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA), hospitalized for treatment of these conditions. Aged = 20 years. Of both sexes. Obese (coexistence of overweight and body fat in obese adults and elderly – Body Mass Index BMI= 25 kg/m2 and > 27 kg/m2, for adults and the elderly, respectively, i.e., overweight BMI for both age groups and, necessarily, increased waist circumference (WC) = 80 cm increased for women and = 90 cm for men) and/or excess body fat according to Triceps Skinfold (PCT) - TSF > 95th percentile for sex and age OR % adequacy > 120% when the PCT obtained / PCT percentile 50 x 100 > 120%, increased WC and PCT constitute obesity/excess adipose tissue, in individuals with overweight/overweight BMI). Clinically stable. With conditions for telephone contact and/or other form of remote contact after hospital discharge
Exclusion criteria
Exclusion criteria: Individuals hospitalized for treatment of Acute Myocardial Infarction (AMI) and Cerebrovascular Accident (CVA). With – Body Mass Index BMI < 25 kg/m2 (adults) and <= 27 kg/m2 (elderly). Clinically unstable. With special needs (assisted feeding, such as enteral feeding). No conditions for telephone contact and/or other form of remote contact after hospital discharge. Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to observe an attenuation of the inflammatory process obtained in PCR analyzes using the Turbidimetry method and Interleukins (IL-8, IL-6, IL-10 and TNF alpha) using the ELISA method within a period of 6 months, from the observation of a variation of at least 5% in pre- and post-intervention measurements | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to observe an attenuation of oxidative stress with an increase in antioxidant defenses Glutathione and antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, analyzed by the methods of Akerboom and Sies (1981), RANSOD kit - RANDOX Brasil LTDA, method of Aebi (1984) and RANSEL kit - RANDOX Brasil LTDA, respectively, and, with a decrease in the oxidative damage marker Malondialdehyde, analyzed using the thiobarbituric acid reactive substances method (TBARS), over a period of 6 months, based on the observation of a variation of at least 5% in pre- and post-intervention measurements | — |
Countries
Brazil
Contacts
Public ContactSandra Mary Vasconcelos
Universidade Federal de Alagoas. Faculdade de Nutrição. Laboratório de Nutrição em Cardiologia (NUTRICARDIO)
Outcome results
None listed