Chronic Periodontitis, Diabetes Mellitus
Conditions
Interventions
This is a split-mouth desing study in which twenty-five diabetics with chronic periodontitis on supportive periodontal therapy were selected (HbA1c bigger or equal to 6, 5%). In each patient, all resi
(2) SRP in single session and irrigation with Curcumin 100 mg/ml solution (CUR Group)
(3) SRP in single session, irrigation with saline solution and irradiation with LED (LED group)
(4) SRP in single session, irrigation with CUR solution, followed by LED irradiation (aPDT Group). The antimicrobial photodynamic therapy (aPDT) was performed using CUR (100 mg / ml) followed by LED i
Procedure/surgery
Other
E06.721.189.350
E02.186.500
Sponsors
Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba
Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba
Eligibility
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with age equal to or greater than 30 years and less or equal than 70 years (MATARAZZO et al., 2008); diagnosis of chronic periodontitis that have undergone periodontal treatment in a period of 3 to 6 months, with at least 4 sites with probing depth (PD) bigger or equal than 5 mm and loss of clinical attachment (CAL) bigger or equal than 3 mm with bleeding on probing (BOP) (APP, 2015); patients diagnosed with type 2 diabetes mellitus (HbA1c equal to or greater than 6.5%) (SACKS et al., 2011); present at least 15 teeth, excluding third molars (ASSEM, 2015); at least 1 site with PD equal to or greater than 5 mm (residual pocket with bleeding on probing) per quadrant.
Exclusion criteria
Exclusion criteria: Smokers or ex-smokers for more than 12 months; patients with anemia; patient with active cancer and history of chemotherapy; history of antibiotic therapy in the previous 6 months; history of anti-inflammatory therapy in the last 6 months; patient with blood disorders; pregnancy; patient in orthodontic treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study will be the mean of changes in the level of clinical attachment in moderate and deep pockets. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical evaluation of visible plaque index, bleeding on probing, gingival recession and probing depth after 90 and 180 days of periodontal treatment. | — |
Countries
Brazil
Contacts
Public ContactLeticia Theodoro
Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatuba
Outcome results
None listed