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Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.

Resistance training in clinical, inflammatory process control in patients with moderate, severe and difficult control asthma.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-4tbd4p
Enrollment
Unknown
Registered
2012-05-11
Start date
2012-01-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Quality of life

Interventions

The subject will be initially evaluated and randomized into 2 groups (1 Group (intervention)-20 participants and group 2 (control)-20 participants) and subjected to resistance training and educational
b) use appropriate medications for each patient and with the proper technique
c) know how to recognize when the asthma is coming out of control, and how to act in the presence of an exacerbation
d) know the side effects of the medications used and understand how to minimize them
and learn to monitor their illness) using the peak flow meter. The lessons will be given in the form of lectures and group discussion. Program of resistance training: the training program will last 12
other
SP1.011.122

Sponsors

Universidade Nove de Julho
Lead Sponsor
Universidade Nove de Julho
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: In medical treatment-outpatient for at least six months; Clinical picture stable for three months; Optimized drug therapy.

Exclusion criteria

Exclusion criteria: Heart disease associated with pulmonary disease; Musculoskeletal pathology that may interfere with the conduct of reviews or exercises; Pulmonary hypertension; Difficulty to learn.

Design outcomes

Primary

MeasureTime frame
Reduction of inflammatory process ápós resistance training, assessed by analysing the levels of cytokines by ELISA. Levels of interleukin-2 (IL-2), IL-4, IL-5 and IFN as well as levels of leukotrienes are analysed using commercial kits of enzyme immunoassay (EIA). All samples will be evaluated in duplicates. Improves lung function, evaluated through the procedure of simple pulmonary function test performed respecting the rules of CONSENSUS I BRAZILIAN SPIROMETRY (1996). The dynamic indices obtained will be: forced vital capacity (FVC); Forced Expiratory volume in one second (Fev1); peak flow (PFE) and forced expiratory flow 25-75; Tiffeneau index (VEF1CVF); and maximum voluntary ventilation (VVM). Increased quality of life, evaluated using the questionnaire of quality of life for asthma that evaluates the domains: physical limitation (activities of daily living and leisure), frequency, and severity of symptoms, adherence to treatment, psychosocial and socioeconomic situation. Should be applied by an interviewer, who is not involved with the study, and that will be trained not to interpret the questionnaire for patients. Decrease in anxiety and depression, measured through the self-esteem that will be evaluated by Rosemberg scale. As regards the other variables will be used the questionnaires of BECK et al. for anxiety and depression SPEILBERGER et al. questionnaires are applied by an interviewer that is not involved with the study-oriented, not provide interpretations for patients. Decrease of clinical symptoms, analysed by a journal designed specifically for this job, but based on a previously described (Robles, 2003). The journals will be filled out daily by patients and include questions about the emergence of crises and symptoms (cough, wheezing, shortness of breath, "" wake up the night ", using" firecrackers "). The days free from any of the symptoms will be totaled and considered monthly. Increased peak Expiratory flow values (PFE), assessed through the daily

Secondary

MeasureTime frame
Increasing peripheral muscle strength after resistance training, assessed by testing of maximum force. Before the performance of the tests of 1 repetition (1RM), patients will search four training sessions for learning exercises. After this period, the load test will be applied to assess the 1RM maximum strength exercises: supine straight (SR), leg press (LP), pulled behind (en), hack (HACK), 45th biceps with dumbbells (RB), leg extension (EP) and triceps doughnut in the pulley (RT). Decreased level of respiratory discomfort against determined physical effort, evaluated by numerical scale of Borg modified, ranging from 0 (lowest effort) to 10 (most effort). Decreased heart rate variability (FC), evaluated by the test of variability of FC held on an air-conditioned laboratory with temperatures between 22 and 24° C and air humidity between 50 and 60, in the same period of the day (between 8:0 and 12:0). For the day before and on the day of the test, each volunteer will receive the following guidelines: avoid stimulating beverages (tea, coffee, alcoholic beverages ...), not to make physical activity, perform light meals and have a proper night's sleep (at least 8:0). Before the start of collections, participants will be questioned and examined – systolic blood pressure measurement (PAS) and diastolic arterial pressure (PAD), heart rate (HR), listens to pulmonary and peripheral oxygen saturation. Initially the volunteers will be kept for approximately 10 min to sleep in the supine position so that the FC reaches the basal values. Instant will be collected later FC during 15 min at rest in the supine position. During the gathering, the volunteers will be geared not to speak, not moving and keep your breath and spontaneous in orthostatic position. Throughout the procedure patients are being monitored by polar frequency.

Countries

Brazil

Contacts

Public ContactLuciana Sampaio

Universidade Nove de Julho

lucianamalosa@terra.com.br11-96002075

Outcome results

None listed

Source: REBEC (via WHO ICTRP)