Hypertension
Conditions
Interventions
Each participant performed the multi-component physical training program (various skills and motor skills) for a period of 12 weeks, twice a week, on non-consecutive days, and each session lasted 90 m
NOBLE, 1974), maintaining the intensity between 13 (a little intense) and 15 (intense/heavy). Participants were initially and constantly instructed and encouraged to assess the workout load and progre
Other
I02.233.543
G11.427.410.698.277
Sponsors
Escola de Educação Física e Esporte de Ribeirão Preto
Escola de Educação Física e Esporte de Ribeirão Preto
Eligibility
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Men and women with different levels of physical activity and aged between 50 and 80 years.
Exclusion criteria
Exclusion criteria: To present some medical, mental or musculoskeletal conditions that could prevent the performance of the motor tests and the physical training program; presenting a body mass index greater than 35 kg/m2, resting systolic blood pressure greater than 160 mmHg and resting diastolic blood pressure greater than 100 mmHg; have a frequency of less than 75% in the activities proposed by the intervention (in this case, it would not carry out the reassessment; only initial data used in the cross-sectional analysis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The response of systolic and diastolic blood pressure of absolute and relative form of participants in different genotypes and haplotypes (interaction between genotypes) related to the genetic variants of endothelial nitric oxide synthase (eNOS): -786T>C, G894T and intron 4b/a; angiotensin-converting enzyme (ACE) and angiotensin II type I receptor (AGTR1); e, alpha-actinin 3 (ACTN3) after 12 weeks of multicomponent training Blood pressure was measured using an automatic arm digital pressure gauge (OMRON brand, model HEM-7113), which uses the oscillometric measurement method. ;Influence of genetic characteristics on the response to training on systolic (SBP) and diastolic (DBP) blood pressure was expected. And this outcome was observed as described below:;In the isolated analysis of eNOS genetic variants (-786T>C, G894T, íntron 4b/a), it was possible to observe a significant reduction of systolic (SBP) and diastolic blood pressure (DBP) in homozygotes with ancestral alleles and also in genotypes with variant alleles. Still, it is worth mentioning that homozygotes with the ancestral alleles presented better response in SBP and DBP. In the analysis, according to the prehypertensive and hypertensive groups, the three groups of the genotypes with the variant alleles demonstrated no response in the PAD in the hypertensive group. In the isolated analysis of the ACE genetic variants, the three genotypes showed improvement in SBP, however in DBP, only the genotypes ID and II. The DD genotype showed no improvement in DBP. Regarding the AGTR1 genotypes, both the AA genotype and the AC + CC group showed improvements in SBP and DBP. Regarding the eNOS haplotype analysis, H1 haplotype (three homozygous subgroups with ancestral alleles) was the only one to show improvement in SBP and DBP. And about the ACE and AGTR1 haplotypes, all showed improvement in SBP; however, the two haplotypes in which the DD genotype, H1, and H4 were present, there was no improvement in DBP. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 - The response of nitrite concentration (stable nitric oxide metabolite); of oxidative stress by the concentration of malondialdehyde; of the antioxidant activity through the total antioxidant capacity (blood analysis in the laboratory); and physical fitness by aerobic resistance motor tests and upper and lower limb strength of participants in the different genotypes and haplotypes (interaction between genotypes). 2 - Response in physical fitness (motor tests) and quality of life (questionnaire SF - 36) according to the level of physical activity;1 - The influence of the genetic variants of eNOS in nitrite and ECA and AGTR1 in CAT was expected. There was also some evidence in the literature about the influence of these genetic variants on physical fitness. Of these outcomes, only the influence of AGTR1 genetic variants on CAT was not observed, since both groups showed improvement. The other outcomes were observed as described below: 2 - It was expected that the insufficiently active group would have a good response to the physical exercise program, while the active and very active group had less responses.;1 - In the eNOS genetic variants, in the isolated analysis of each polymorphism, on the nitrite concentration, all groups showed an improvement, except for the groups with the variant allele. Polymorphisms did not influence the response of malondialdehyde (MDA), total antioxidant capacity (TAC), and physical fitness since all groups showed improvement. The haplotype H1 (three homozygous subgroups with ancestral alleles) was the only one to show improvement in all the studied variables. In contrast, haplotype H8 (three subgroups with polymorphic alleles) showed only a decrease in MDA and an increase in physical fitness. The effect of multicomponent training in the analysis without division by genotypes and according to the prehypertensive and hypertensive groups was similar. Still, taking into account, the subgroups with the ancestral alleles in the three gen | — |
Countries
Brazil
Contacts
Public ContactAtila Trapé
Escola de Educação Física e Esporte de Ribeirão Preto
Outcome results
None listed