Polycystic ovary syndrome, cardiac autonomic modulation, body mass index, adipokines.
Conditions
Interventions
Polycystic Ovary Syndrome untreated (PCOS group, n=60) and control group without the syndrome (control group, n=60): 120 women (33 ± 3 years) who were divided into two groups were studied. Each group
Other
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women aged between 18 and 40 healthy years and diagnosed with polycystic ovarian syndrome belonging to the outpatient clinic of Gynecology and Obstetrics of the University were not engaged in regular physical activity (least 2 times per week)
Exclusion criteria
Exclusion criteria: Exclusion criteria: women in use of contraceptives or other drug treatment, smoker (regular consumption of cigarettes or tobacco-derived.); alcoholic (physical and psychological dependence on alcohol); who had mental disorders that hindered the understanding and execution of tests; disabling musculoskeletal disorders (osteoporosis, fractures unconsolidated, muscular dystrophy, low back pain) and cardiovascular disease (myocardial infarction, heart failure, arrhythmias).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Women with Polycystic Ovary Syndrome (PCOS)may exhibit decreased sympathetic influence and increased parasympathetic activity as assessed by spectral analysis of heart rate and comparing pre and post program of aerobic exercise training conditions.;Women with PCOS and women in the control group showed no differences in autonomic modulation in the evaluation of spectral analysis of heart rate after aerobic exercise training program.;Women with PCOS may experience metabolic changes, measured through blood samples and tests specific radioimmunoassay, as increased fasting glycemia (blood glucose> 110mg/dL); reduced insulin sensitivity observed in the glucose tolerance test of 75gramas (value of glycemia> 140mg/dl after 2 hours); increasing blood levels of leptin (blood dosage> 17ng/mL), interleukin-6 (blood dosage> 5 pg / mL) and factor-alpha tumor necrosis factor (blood dosage> 8 pg / ml), and decreased levels of adiponectin (reference value of blood: 5-30 mg / mL) and these variables influenced by aerobic exercise training program.;The program of aerobic exercise training in PCOS group promoted beneficial on many factors evaluated effects, such as increased adiponectin and decreased interleukin-6 and TNF-alpha, however, its greatest effects were on glucose tolerance, fasting insulin and leptin. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increased body fat may alter the autonomic modulation and metabolic markers after the exercise training program. For this, the PCOS group and the control group were divided into 3 subgroups each, according to the percentage of body fat (22-27%, 27-32% and 32-37%) assessed by bioelectrical impedance.;The program of aerobic exercise training caused a decrease in blood glucose levels of the PCOS groups with higher percentages of body fat (27-32% and 32-37%), values ??similar to those observed in the group with lower body fat percentage (22 - 27%). As for the values ??of leptin, all groups decreased after training, however the SOP group trained with greater body fat percentage (32-37%) showed higher values ??than the other. Regarding adiponectin, aerobic exercise training promoted an increase in the groups with higher percentages of body fat, generating similar values ??among all trained groups. Finally, analysis of IL-6 after exercise training showed that the group with the highest percentage of body fat declined significantly, however, this group also showed higher values ??compared to the other groups also trained. | — |
Countries
Brazil
Contacts
Public ContactAna Paula;Ana Paula Pereira;Pereira
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo;Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Outcome results
None listed