Hypertension
Conditions
Interventions
High-intensity interval training group: 22 hypertensive older adults will be submitted to an aerobic training program during 12 weeks. The program will consist of 3 sessions per week of walking/joggin
Behavioural
G11.427.410.698.277
E02.760.169.063.500.387
G11.427.410.698.277.311.250
Sponsors
Universidade Federal do Rio Grande do Norte – UFRN
Hospital Universitário Onofre Lopes – HUOL
Eligibility
Inclusion criteria
Inclusion criteria: Both sexes; aged 60-80 years; previous diagnosis of hypertension; self-reported and clinically assessed physical activity readiness; unchanged pharmacological plan for hypertension in the last 4 weeks; willing to engage in any of the interventions; not engaging in a regular physical activity program in the past 3 months; insufficiently active (i.e., not performing 150 min/week of moderate physical activity and/or 75 min/week of vigorous physical activity, assessed through 7-day accelerometry)
Exclusion criteria
Exclusion criteria: Being unable or refusing to sign the consent form; previous cardiovascular events or diseases (e.g. unstable angina, severe arrhythmia, acute myocardial infarction, coronary artery disease, stroke, deep vein thrombosis, peripheral artery disease, uncontrolled arrhythmia, pacemaker use, etc.); limiting chronic pulmonary disease (emphysema, chronic bronchitis, asthma); chronic kidney disease in need of dialysis; incidence of cardiovascular or pulmonary events during the study; uncontrolled hypertension (> 160/105 mmHg); diabetes with insulin use or decompensated (fasting glucose > 300 mg/dl); high alcohol intake (>14 doses per week); self-reported or perceived language, hearing or sight limitations that may come to hinder participation; exercise contraindication, as indicated on the maximum cardiopulmonary exercise test (e.g. EKG alterations suggesting myocardial ischemia); osteomioarticular issues that may prevent performing maximal cardiopulmonary exercise testing and moderate-to-vigorous aerobic exercise or osteomioarticular injury during the study (e.g. muscle injury resulting in limitations for exercise); neurological progressive disorders (Parkinson, multiple sclerosis, Alzheimer); cancer demanding treatment in the past two years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in ambulatory systolic blood pressure levels after 12 weeks of aerobic training, assessed through ambulatory blood pressure monitoring, through the confirmation of a decrease of at least 4 mmHg between pre- and post-intervention measurements compared to the control group | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved brain hemodynamics in the pre-frontal cortex in response to cognitive task after 12 weeks of aerobic training, assessed through near infrared spectroscopy (NIRS) and computerized Stroop test, through the confirmation of a statistically significant decrease (p 0.05) after 12 weeks of aerobic training, assessed through triaxial accelerometry, in the pre- and post-intervention measurements compared to the control group;No significant changes in sedentary behavior (p >0.05) after 12 weeks of aerobic training, assessed through triaxial accelerometry, in the pre- and post-intervention measurements compared to the control group;No significant changes in food intake (p >0.05) after 12 weeks of aerobic training, assessed through 24-hour dietary recall questionnaire, in the pre- and post-intervention measurements compared to the control group;Decrease in ambulatory diastolic blood pressure levels after 12 weeks of aerobic training, assessed through ambulatory blood pressure monitoring, through the confirmation of a statistically significant decrease (p <0.05) between pre- and post-intervention measurements compared to the control group;Decrease in resting blood pressure levels after 12 weeks of aerobic training, assessed through an oscillometric blood pressure monitor, through the confirmation of a statistically significant decrease (p <0.05) between pre- and post-intervention measurements compared to the control group;Decrease in central arterial (aortic) resting pressure levels after 12 weeks of aerobic training, assessed through ambulatory blood pressure monitoring, through the confirmation of a statistically significant decrease (p <0.05) between pre- and post-intervention measurements compared to the control group;Decrease in resting arterial stiffness (pulse wave velocity) after 12 weeks of aerobic training, assessed through ambulatory blood pressure monitoring, through the confirmation of a statistically significant decrease (p <0.05) between pre- and post-int | — |
Countries
Brazil
Contacts
Public ContactEduardo;Rodrigo Costa;Browne
Universidade Federal do Rio Grande do Norte - UFRN;Universidade Federal do Rio Grande do Norte – UFRN
Outcome results
None listed