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Efficacy of a New Device to prevent Cervical Narrowing after Conization

Efficacy of an Intracervical Device (ICD) in preventing Cervical Stenosis following Type III Excisional Procedure (Conization) of the uterine cervix

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
REBEC
Registry ID
RBR-4njwqsw
Enrollment
Unknown
Registered
2025-08-08
Start date
2025-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conization

Interventions

This is a two-arm, single-blind, randomized controlled clinical trial. Experimental group: 233 women indicated for cervical conization will receive an Intracervical Device (under patent review) aimed

Sponsors

Fundação Oswaldo Cruz
Lead Sponsor
Fundação Oswaldo Cruz
Collaborator

Eligibility

Sex/Gender
Female
Age
25 Years to No maximum

Inclusion criteria

Inclusion criteria: Women indicated for type III excision (conization) of the uterine cervix; women aged 25 and older

Exclusion criteria

Exclusion criteria: Women with any history of previous excisional procedures (regardless of type or timing); pregnant women; women who become pregnant within 90 days following the excisional procedure

Design outcomes

Primary

MeasureTime frame
A 64% reduction in the risk of stenosis of the external os of the cervix is ??expected, verified by the possibility or not of introducing a brush to collect cytological material from the endocervix in 90, 180 and 360 days (and at any time until censorship).

Secondary

MeasureTime frame
Excessive bleeding measured by the woman's information that she noticed vaginal bleeding that was greater than her usual menstrual period or that required her to use more than two sanitary pads per day;Report of pain during the menstrual period in previously asymptomatic women or worsening of this symptom in those who already had it;Woman reports vaginal discharge that is different from usual;Report of unwanted vaginal odor;Report of discomfort during sexual intercourse for those who did not have it or worsening for those who already had this symptom;Request for device removal before 90 days;Other complaints reported by participants

Countries

Brazil

Contacts

Public ContactMaria Camargo

Fundação Oswaldo Cruz

mariaj.camargo59@gmail.com+5521999777009

Outcome results

None listed

Source: REBEC (via WHO ICTRP)