Pulmonary tuberculosis.
Conditions
Interventions
728 subjects will be recruited respecting the inclusion / exclusion criteria. These will be divided into two groups of 324 individuals, called experimental and control, respectively. A simple individu
Drug
Sponsors
Ministério da Ciência, Tecnologia, Inovações e Comunicações
Universidade Federal de Mato Grosso do Sul
Universidade Federal da Grande Dourados
Fundação Oswaldo Cruz - Unidade Cerrado Pantanal
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Minimum stay estimated at 24 months under a closed regime; age between 18 and 45 years; without active tuberculosis or previous use of isoniazid; without consuming alcohol at least 3 months.
Exclusion criteria
Exclusion criteria: Positive serology for HIV, hepatitis B and C; latent tuberculosis; liver enzymes three times the upper limit; use of any medication that influence the metabolism of P450 enzyme; acute or chronic renal failure; epilepsy; indigenous.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50% of latent tuberculosis infection after 12 months of imprisonment.;50% of active tuberculosis after 12 months of imprisonment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of 50% of latent tuberculosis after 24 months of imprisonment.;Reduction of 50% of active tuberculosis after 24 months of imprisonment. | — |
Countries
Brazil
Contacts
Public ContactJulio;Roberto Croda;Oliveira
Universidade Federal da Grande Dourados;Universidade Estadual de Mato Grosso do Sul
Outcome results
None listed