Depressive disorder
Conditions
Interventions
This is a randomized crossover study. 50 volunteers of both genders aged 20-45 years will be recruited and divided into two groups: a) Control Group (n=25) - Composed of healthy individuals, and b) De
b) Aerobic exercise performed at 85% of Vpeak (vigorous intensity) until maximum voluntary exhaustion. At baseline, immediately after and 30 minutes after the end of the exercise, the volunteers will
G11.427.410.698.277
I03.350
Sponsors
Universidade Federal de São Paulo
Universidade Federal de São Paulo
Eligibility
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Both genders. Age between 20 and 45 years. With a minimum schooling time of 8 years. affected or not by depressive disorder, the latter with a diagnosis of at least 3 months. Considered minimally active. Considered in good health after medical evaluation. They must not have undergone surgery in the last 6 months. Must not have any physical, muscle and/or joint problems
Exclusion criteria
Exclusion criteria: Those who, for whatever reason, do not complete the tests within the stipulated period will be excluded from the sample
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It is expected to find improvements in mood states after moderate and vigorous intensity exercises and kynurenine pathway metabolites, verified by Brunel Mood Scale, State Anxiety Inventory, Visual Analog Mood Scale and Subjective Scale of Exercise Experience and blood analyzes of kynurenine pathway metabolites, through questionnaire scores and increase in kynurenine metabolites, based on verification of at least 5% variation in measurements, immediately after and 30 minutes after the end of the exercise | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are not expected | — |
Countries
Brazil
Contacts
Public ContactCyro Borges
Universidade Federal de São Paulo - UNIFESP
Outcome results
None listed