Calculus of bile duct with cholecystitis, postoperative nausea and vomiting
Conditions
Interventions
Experimental group: 106 patients undergoing laparoscopic cholecystectomy surgery will be given intravenous palonosetron 0.075 mg, before anesthesia induction. Control group: 106 patients undergoing la
Sponsors
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Eligibility
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adult patients undergoing elective laparoscopic cholecystectomy; both genders; 18 to 65 years old; physical status I and II according to American Society of Anesthesiology (ASA)
Exclusion criteria
Exclusion criteria: Use of antiemetic drugs for 48 hours before surgery; those with hiatal hernia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea and/or vomiting incidence, verified by clinical observation and reported as yes or no, according to the presence of the symptom. The noninferiority will be 15%, meaning that the superior limit of the confidence interval for the incidence of nausea and vomiting in palonosetrona group will have to be less than 15% to accept the noninferiority hypothesis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total dose of dimenhydrinate (rescue medication) used, verified by its administration (yes or no), reported as the need of use. It is expected that 30 doses of dimenhydrinate in each group will be administered. | — |
Countries
Brazil
Contacts
Public ContactPaulo do Nascimento Junior
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Outcome results
None listed