Skip to content

Effectiveness of bleaching with carbamide peroxide using sonic ativation and genetic toxicity

Effectiveness of bleaching with 37% carbamide peroxide with and without sonic activation and genotoxic effect: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-4kzgt4
Enrollment
Unknown
Registered
2019-10-22
Start date
2015-10-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth discoloration

Interventions

The study is a randomized clinical trial, split-mouth, double-blind. Fifty-six patients were selected for this study, in which two bleaching sessions will be held with an interval of one week. Both i
In the control with 38% hydrogen peroxide (n = 28), the bleaching was performed for a consecutive period 45 min and 40 min, respectively. In addition, the bleaching gels were applied with and without
Procedure/surgery
E06.420.750

Sponsors

Universidade Federal do Amazonas - Faculdade de Odontologia
Lead Sponsor
Universidade Federal do Amazonas - Faculdade de Odontologia
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients included in this clinical trial were men and women over 18 years; who were in good general and oral health; with six maxillary and mandibular anterior teeth without caries lesions or restorations; the right superior incisor should be shade C2 or darker as judged by comparison with a VITA Classical value-oriented shade guide (Vita Zahnfabrik, Bad Säckingen, Germany)

Exclusion criteria

Exclusion criteria: Pregnant or lactating patients were excluded; smokers; bruxism habits; severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth); orthodontic appliance users; gingival recessed; exposed dentine; who took anti-inflammatories, analgesics or antioxidants.

Design outcomes

Primary

MeasureTime frame
The color difference between the initial condition and after bleaching (1 week and 1 month) will be assessed using the Vita Classical (visual) and Vita Bleachedguide color scales and also with the Vita Easyshade (instrumental) spectrophotometer. Expected Outcome 1: 38% PH and 37% PC gels will produce similar whitening effectiveness when not sonically activated.;Outcome 1: In both visual and color instrumental evaluation, the whitening effectiveness was found to be the same for both 37% carbamide peroxide and 38% hydrogen peroxide.;Expected Outcome 2: The use of sonic activation will not change the effectiveness of whitening with 37% carbamide peroxide.;Outcome found 2: In both visual and instrumental color evaluation, it was observed that the whitening effectiveness was higher in the control and experimental groups where the sonic activation was not used.

Secondary

MeasureTime frame
Number of patients reporting spontaneous pain at any time during the tooth whitening technique and up to 48 hours after the procedure through self-report. This number will be transformed into percentage of patients with pain and will be called absolute risk of dental sensitivity. Expected Outcome 3: The use of sonic activation will not influence the sensitivity risk associated with 37% carbamide peroxide bleaching..;Outcome found 3: There was a statistically significant increase in the absolute sensitivity risk in the groups with sonic activation of the whitening gel, with the hydrogen peroxide group at 38% H presenting the highest percentage (55%).;The intensity of dental sensitivity will be evaluated using the visual analog scale VAS (0-10) and will be presented as mean and standard deviation at different periods (during tooth whitening, up to 1 h, from 1 h to 24 h and from 24 to 48 h after -whitening). Expected Outcome 4: The use of sonic activation will not influence the intensity of sensitivity associated with 37% carbamide peroxide bleaching.;Outcome found 4: Tooth sensitivity was higher in the groups where the sonic activation of the gel was performed, both in the 37% carbamide peroxide group and in the 38% hydrogen peroxide group.

Countries

Brazil

Contacts

Public ContactJuliana de Sá

Universidade Federal do Amazonas - Faculdade de Odontologia

julianalopesdesa@hotmail.com+55-092-988012627

Outcome results

None listed

Source: REBEC (via WHO ICTRP)