Study comparing Levobupivacaine and Ropivacaine in pain relief after foot and ankle surgeries

Use of Levobupivacaine (S75-R25) 0.25% and Ropivacaine 0.25% in sciatic-popliteal nerve block for postoperative analgesia in foot and ankle surgeries: a randomized and double-blind study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-4ks3bmv

Enrollment

Registered

2026-03-26

Start date

2026-05-29

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Foot

Interventions

This is a randomized, controlled, two arm, double-blind clinical trial. The aim of this study will be to compare the duration of postoperative analgesia using levobupivacaine (S75:R25) 0.25% and ropiv

Eligibility

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective foot and ankle surgery; both sexes; aged between 18 and 70 years; with ASA I and II physical status, according to the classification of the American Society of Anesthesiologists; body mass index (BMI) < 30

Exclusion criteria

Exclusion criteria: Patients with peripheral neuropathies; declared allergies to the medications used; coagulation disorders; popliteal fossa infection; pregnant women; those who have undergone medial malleolus surgery

Design outcomes

Primary

Measure	Time frame
To analyze the duration of analgesia produced by sciatic nerve blocks at the popliteal level with Group L and Group R in elective foot and ankle surgeries. The duration of analgesia will be determined by the interval between the sciatic-popliteal nerve block and the patient's first request for analgesia with tramadol (generic medication, União Química) 1 mg/kg IV. Postoperative pain will be assessed after 4h, 8h, 12h, and 24h after sciatic-popliteal nerve block using the Visual Analogue Scale (VAS) on a numerical scale.	—

Measure

Time frame

To analyze the duration of analgesia produced by sciatic nerve blocks at the popliteal level with Group L and Group R in elective foot and ankle surgeries. The duration of analgesia will be determined by the interval between the sciatic-popliteal nerve block and the patient's first request for analgesia with tramadol (generic medication, União Química) 1 mg/kg IV. Postoperative pain will be assessed after 4h, 8h, 12h, and 24h after sciatic-popliteal nerve block using the Visual Analogue Scale (VAS) on a numerical scale.

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Secondary

Measure	Time frame
Two secondary outcomes will be evaluated: motor block and rebound pain. Motor block will be assessed by the patient's ability to dorsiflex or plantar flex the foot of the operated lower limb: 4h, 8h, 12h, and 24h after sciatic nerve block of the popliteal nerve. Rebound pain will be assessed as the presence of pain greater than 7 on the Visual Analogue Scale (VAS) after completion of the sciatic nerve block of the operated limb.	—

Measure

Time frame

Two secondary outcomes will be evaluated: motor block and rebound pain. Motor block will be assessed by the patient's ability to dorsiflex or plantar flex the foot of the operated lower limb: 4h, 8h, 12h, and 24h after sciatic nerve block of the popliteal nerve. Rebound pain will be assessed as the presence of pain greater than 7 on the Visual Analogue Scale (VAS) after completion of the sciatic nerve block of the operated limb.

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Countries

Contacts

Public ContactIrene Kina

Universidade Federal do Rio de Janeiro

kinairene@gmail.com+55-21-997128821

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Apr 4, 2026