Cognitive Dysfunction
Conditions
Interventions
Intervention groups
Participants from the control group (n=25) will not perform any supervised exercise program during the study. For these individuals, the research team will hold a weekly group mee
Other
G11.427.410.698.277
E02.760.169.063.500.387.875
Sponsors
Universidade de Pernambuco - UPE (Campus Petrolina)
Universidade Federal do Vale do São Francisco - UNIVASF
Eligibility
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: The eligibility criteria will be: i) age between 65-80 years; ii) physically inactive (structured exercise classes in the last 3 months); iii) Montreal Cognitive Assessment (MoCA) score lower than 26 (out of a total of 30); iv) absence of clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit; v) no previously diagnosed cerebrovascular, neurological or psychiatric disease; and vi) have sufficient visual and hearing capacity to complete cognitive assessment protocol.
Exclusion criteria
Exclusion criteria: Exclusion criteria: clinical conditions or unstable disease that contraindicates supervised exercise based on medical judgment (cardiologist) during the health screening visit; previously diagnosed cerebrovascular, neurological or psychiatric disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Changes in the global neurocognitive function scores obtained by the sum of the following neuropsychological tests: stroop color test, trail making test part A and B, Digit span forward & backward, digit symbol substitution test, verbal fluency, Time up & go with cognitive demand, and logical memory | — |
Secondary
| Measure | Time frame |
|---|---|
| 2) Changes in the scores of neurocognitive tests related to each cognitive domain: a) Global: Montreal Cognitive Assessment (MoCA); b) Executive functions: stroop test, trail making test part A & B, digit span backward & forward, digit symbol substitution test, time up & go with cognitive demand, verbal fluency (animal and naming); c) Memory: logical memory (immediate and delayed recall);3) Changes (%) in the concentrations of different blood cytokines [(BDNF), and IGF-1 (Insulin-like growth factor) and interleukins (TNF-alpha tumor necrosis factor alpha; IL-1, IL -6 and IL-10)] related to processes of neurogenesis, angiogenesis and inflammation, through the ELISA kit;4) Improvements of functional performance and muscle strength from changes in scores, distance (meters), time (seconds) and percentages (%) in the following tests: a) Short physical performance battery; b) Six-minute walk test (meters); c) time up & go with and without cognitive demand (seconds); d) 1-RM (%); maximum voluntary contraction (%) and peak torque (%).;5) Changes in the amplitude of the center of mass (cm) obtained by a force platform;6) Changes in the fear of falling scores obtained by Fall Efficiency Scale score;7) Percentual (%) changes in the fat and muscle mass obtained by DXA;8) Changes in blood pressure (mmHg) and heart rate variability (arbitrary units), obtained by an automatic pressure monitor and a validated heart monitor. | — |
Countries
Brazil
Contacts
Public ContactRodrigo de Araújo
Universidade de Pernambuco - UPE (Campus Petrolina)
Outcome results
None listed