Prevention - Mediators of inflammation, inflammation
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers; aged between 18 and 40; with teeth free of carious lesions; free of periodontal disease; at least an upper anterior tooth color A2 or higher value.
Exclusion criteria
Exclusion criteria: Volunteers with poor oral hygiene; pregnant women; breastfeeding; patients who have already done tooth whitening; smoking; with restorations in anterior teeth; endodontic treatment; dental prosthesis on anterior teeth; presence of dental cracks, gingival recessions; carious cervical lesions; fractures; spontaneous tooth sensitivity; severe internal discoloration; bruxism habits; patients who use drugs with analgesic or anti-inflammatory effect; patients with fixed orthodontic appliances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| color difference between the sides cleared the end of the study, verified by classical vita scale bleaching vita and the Spectrophotometer Easy Shade device, from finding a variation of at least three points in pre and post intervention analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| sensitivity difference between the whitened sides, checked on a scale (NRS) and visual analogue scale (VAS), from finding a variation of two points on a scale and four-point visual analog scale in the analysis pre and post intervention. Difference in cytokine levels in the gingival crevicular fluid (inflammation) after bleaching, through the concentration of inflammatory mediators (interleukins) in the analysis pre and post intervention . Difference in the volume of gingival crevicular fluid after bleaching, checked by the amount of fluid present in the analysis pre and post intervention. | — |
Countries
Brazil
Contacts
Universidade Ceuma