Coronavirus Infections
Conditions
Interventions
Randomized open clinical trial with the inclusion of 400 health professionals in direct contact with patients suspected of COVID-19. Two hundred individuals will be randomly allocated to each group.
Sponsors
Universidade Federal de Goias
Universidade Federal de Goias
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: HW with BCG scar, adults, over 18 years old,who have negative IgM and IgG COVID-19 test, regardless of gender, dedicating at least 8 hours a week to care for individuals suspected of having COVID-19.
Exclusion criteria
Exclusion criteria: Participants with any of the following characteristics will be excluded: Individuals who have had a fever in the last 15 days; pregnant or lactating women; individuals with suspected viral infection including COVID-19 or bacterial in the past 15 days before randomization; have had a previous diagnosis of tuberculosis; has had a vaccination in the last 15 days; immunocompromised or with neutrophil count below 500 / mm3; using corticosteroids, antibiotics and chemotherapy drugs; present or have presented a solid or non-solid tumor in the last 2 years; or who are directly involved in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of health problems of health care workers related to COVID-19 among individuals vaccinated with BCG, verified by clinical evaluation and laboratory exames during 180 days.;Reduction of positivity for COVID-19 through serological, molecular tests and / or clinical evaluation among individuals vaccinated with BCG. | — |
Secondary
| Measure | Time frame |
|---|---|
| innate immune response induction among individuals in the BCG vaccinated group, verified using citometric analysis of NK and neutrophils cell populations, 15-20 days after vaccination with BCG compared to day one (the day of inclusion in the study). | — |
Countries
Brazil
Contacts
Public ContactAna Paula;André Kipnis;Kipnis
Universidade Federal de Goias;Universidade Federal de Goias
Outcome results
None listed