Pregnancy
Conditions
Interventions
This study aimed to determine the metabolomic profile and metabolic pathway associated with obesity and periodontitis during pregnancy in saliva and plasma biofluids. Initially, 120 pregnant women (du
with obesity, but without periodontitis (OWP = 27)
with normal body mass index, but with periodontitis (NP = 21)
with normal body mass index and without periodontitis (NWP = 30). Data collected for observational analysis referred to contextual parameters (age, schooling and monthly family income), anthropometric
H01.158.201.586
V03.175.500
Sponsors
Faculdade de Odontologia de Bauru - Universidade de São Paulo
King's College London
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Be between 18 and 40 years old; during the 3rd trimester of pregnancy, between the 27th and 39th gestational week; with regular follow-up with the obstetrician; with adequate cognitive function during pregnancy; with no problem that required absolute rest
Exclusion criteria
Exclusion criteria: Twin pregnancies; individuals with neuromotor impairments; arterial hypertension during pregnancy; Gestational Diabetes Mellitus; malnutrition; overweight, therefore, body mass index between 25.00 and 29.99 kg/m2; confirmed or suspected diagnosis of SARS-CoV-2 infection; hyposalivation; subjects who were using or who used at some point in pregnancy antibiotics or any medication that could interfere with periodontal status or salivary flow, e.g. immunosuppressive drugs, anticonvulsants or calcium channel blockers; who were under orthodontic treatment or any dental treatment with another professional; with multiple tooth loss, so more than two teeth per hemiarch; self-reported systemic disease besides obesity; and users of alcohol, tobacco, and illicit drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1. Using proton nuclear magnetic resonance spectroscopy analysis, we expected to identify dysregulation in salivary and plasma metabolite levels associated with obesity and periodontitis during pregnancy, particularly when obesity and periodontitis were present in combination;Identified outcome 1. Using a proton nuclear magnetic resonance spectrscopy analysis, this study demonstrated a more evident difference among groups in saliva samples compared to plasma, mainly related to periodontitis, without notable differences related to obesity. Periodontal parameters were positively correlated with many saliva metabolites, for instance, it was found a dysregulation in the salivary levels of leucine, ornithine, isovaleric acid, valine, isoleucine, putrescine, taurine, phenylalanine, propionic acid, and acetic acid associated with periodontitis | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes expected | — |
Countries
Brazil, United Kingdom
Contacts
Public ContactGerson Foratori Junior
Faculdade de Odontologia de Bauru - Universidade de São Paulo
Outcome results
None listed