Anomalies of tooth position
Conditions
Interventions
This is a two-arm, triple-blind, split-mouth randomized controlled clinical study. There will be 48 patients, 24 in each group. Volunteers may be allocated into one of two groups, following a 2X2 fact
D27.505.954.329.030
Sponsors
Universidade Federal do Ceará
Universidade Federal do Ceará
Eligibility
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Healthy individuals of both sexes; aged between 18-35 years; in need of removal of the two lower third molars; will be invited to participate in this study. In addition to these, the following inclusion criteria will also be adopted: semi-erupted or non-erupted mandibular third molars; third molars that present, on panoramic radiography, similar patterns of root formation, position and degree of impaction when comparing the right and left sides of each volunteer
Exclusion criteria
Exclusion criteria: Volunteers who meet at least one of the following criteria will be excluded: smokers; pregnant or lactating women; users of medications that interact with the drugs used in this study; carriers of orthodontic bands in mandibular second molars; confirmed history of allergy to NSAIDs or corticoids; signs of any preoperative inflammatory or infectious condition; systemic diseases; neurological disorders. In addition, the volunteer who has used any NSAID or corticoid within a period of up to 21 days before the surgical procedure will also be excluded from the research due to the possibility of a residual effect of the drug eventually used, which may influence the outcomes of the present study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate mean differences in clinical parameters related to inflammatory events (pain, edema and trismus). Pain will be assessed through the visual analog scale; Edema will be measured by distances between specific points on the face; Trismus will be evaluated by measuring the mouth opening using a caliper. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the occurrence of quantitative changes in oxidative stress biomarkers, impact on quality of life, sleep quality and pain catastrophizing in patients during the postoperative period. Oxidative stress will be assessed by measuring specific biomarkers, such as nitrate, malondialdehyde and total protein. Quality of life will be assessed using a specific questionnaire, such as the Oral Health Impact Profile (OHIP-14); sleep quality through the Pittsburg Sleep Quality Index - PSQI23 and pain catastrophizing through a specific scale. | — |
Countries
Brazil
Contacts
Public ContactEdson Cetira Filho
Universidade Federal do Ceará
Outcome results
None listed