Pain, Maternal Suffering during labor, women
Conditions
Interventions
A controlled, double-blind, randomized clinical trial was performed on 20 blocks of 10 participants. Pethidine was administered to 100 women in labor (0.25mg / kg) and Dipyrone Sodium was given to 100
Drug
E03.091.110
Sponsors
UNIFOR - Universidade de Fortaleza
Secretaria municipal de saúde de Fortaleza
Eligibility
Sex/Gender
Female
Age
6 Years to 100 Years
Inclusion criteria
Inclusion criteria: Presence of at least 3 uterine contractions lasting 40 seconds or more every 10 minutes; Patients presenting a dilation of the uterine cervix equal to or greater than 5 cm; Measurement of pain through the use of visual analogue scale equal to or greater than 8; Gestational age of 37 up to 40 weeks and 6 days; Fetuses in cephalic presentation
Exclusion criteria
Exclusion criteria: Parturients with any of the following events: poorly controlled arterial hypertension, diabetes, restricted intrauterine growth and placental abruption; Use of oxitocyn by pregnant women in the period from the begining of labor until 2 hours after administration of the analgesic; Hypothyroidism diagnosed previously and without therapy; Patients taking monoamine oxidase inhibitors; Occurrence of labor less than 1 hour after analgesia; Parturients with body mass greater than 100 kg; Indication of cesarean delivery during admission; Addison's disease previously diagnosed; BCF's 160 bpm, during admission; Patients allergic to sodium dipyrone; Patients allergic to pethidine; Users of chlorpromazine; Phenobarbital users; Phenytoin users; Fetus without vilality; Twin pregnancy; Drug addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1. One of the drugs was expected to show superior analgesic potency during labor. The avaluations were carried out between 5/20/2016 and 12/31/2016 ;Found outcome 1. The pain was measured by the visual analog scale just before the intervention, 1 hour and 2 hours after the intervention. Statistical evaluation was done using Student's t-test, ranging up to 1 standard deviation for more or less, at a significance of 5% and a 95% confidence interval. Similar analgesic effect occurred with the 2 drugs 1 hour after the intervention. One hour after the intervention, the score attributed to pain in participants who used Dipirone was 7.97 ± 1.226 and after Pethidine was 8.04 ± 1.271, with a p-value of 0.697. Two hours after the intervention, the two drugs did not present a statistically significant analgesic effect. The avaluations were carried out between 5/20/2016 and 12/31/2016 | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 1. Maternal nausea: no significant difference between the two drugs. The avaluations were carried out between 5/20/2016 and 12/31/2016;Found outcome 1. Using the chi-square test. Maternal nausea: pethidine (7%), dipyrone (6%); p-value of 0.774 (At a significance of 0.05. P-value was > 0.05. The avaluations were carried out between 5/20/2016 and 12/31/2016 ;Expected outcome 2. Presence of meconium in the trachea of newborns: no significant difference between the two drugs. The avaluations were carried out between 5/20/2016 and 12/31/2016;Found outcome 2. Using the chi-square test. Meconium in the trachea of newborn: pethidine (1%), dipyrone (3%); p-value of 0.302 (At a significance of 0.05. P-value was > 0.05). The avaluations were carried out between 5/20/2016 and 12/31/2016;Expected outcome 3. Dilation rate of the uterine cervix: no significant difference between the two drugs. The avaluations were carried out between 5/20/2016 and 12/31/2016;Found outcome 3. Using Student's t-test, ranging up to 1 standard deviation for more or less. Dilation rate of the uterine cervix: pethidine (1.84 cm/h), dipyrone (1.82 cm/h); p-value of 0.925 (At a significance of 0.05. P-value was > 0.05). The avaluations were carried out between 5/20/2016 and 12/31/2016;Expected outcome 4. Heart rate of the concepts 30 minutos after birth: no significant difference between the two drugs. The avaluations were carried out between 5/20/2016 and 12/31/2016;Found outcome 4. Using Student's t-test, ranging up to 1 standard deviation for more or less. Heart rate of the concepts 30 minutos after birth: pethidine (144), dipyrone (143); p-value of 0.443 (At a significance of 0.05. P-value was > 0.05). The avaluations were carried out between 5/20/2016 and 12/31/2016;Expected outcome 5. Apgar in the fifth minute of life: no significant difference between the two drugs. The avaluations were carried out between 5/20/2016 and 12/31/2016;Found outcome 5. Using Student's t-test, ranging up | — |
Countries
Brazil
Contacts
Public ContactRogevando Nunes
UNIFOR - Universidade de Fortaleza
Outcome results
None listed