Deficiency Diseases
Conditions
Interventions
Intervention group: anemic children will receive the NutriSUS strategy sachet supplemented with 3.2 mg/kg/ day of ferrous sulfate in the day care center and non-anemic children will only receive the s
Drug
Dietary supplement
D27.505.696.377.605
Sponsors
Faculdade de Nutrição da Universidade Federal de Goiás
Faculdade de Nutrição da Universidade Federal de Goiás
Eligibility
Age
6 Months to 48 Months
Inclusion criteria
Inclusion criteria: Children aged six to 48 months; anemic and non-anemic.
Exclusion criteria
Exclusion criteria: Children in treatment of anemia; malaria; HIV, hemoglobinopathies or hemochromatosis; low weight at birth; preterm birth (less than 37 weeks); twin; allergies reported to any components of the fortification sachet and/or to ferrous sulfate/folic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the difference in mean serum hemoglobin levels, verified by electronic counting, between children receiving Nutrisus or supplementation with iron and folic acid, measured before and after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Any change in serum vitamin A, verified by High Performance Liquid Chromatography (HPLC), measured before and after the intervention.;Any change in serum vitamin E, verified by High Performance Liquid Chromatography (HPLC), measured before and after the intervention.;Any change in serum vitamin D, verified by amplified chemiluminescence, measured before and after the intervention.;Any change in serum folic acid level, verified by commercial fluoroimmunoassays, measured before and after the intervention.;Presence or absence of rs855791 polymorphism in the TMPRSS6 gene. Genotyping will be performed by real-time polymerase chain reaction (qPCR) using the inventoried assay (TaqMan® SNP Genotyping Assays, Waltham, Massachusetts, USA) for SNPs rs855791 located in the TMPRSS6 gene, which encodes a transmembrane serine protease 6. StepOne equipment will be used (Thermo Fisher Scientific, Massachusetts, USA). | — |
Countries
Brazil
Contacts
Public ContactMaria Claret Hadler
Universidade Federal de Goiás
Outcome results
None listed