Periodontitis
Conditions
Interventions
The test group will consist of 60 individuals who will receive standard non-surgical periodontal treatment. This treatment will consist of a scaling, straightening and polishing coronal-radicular and
Procedure/surgery
Behavioural
E06.721.189.350
Sponsors
Universidade Federal do Rio Grande do Sul
Universidade Federal do Rio Grande do Sul
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Stage 3 and 4 chronic kidney disease; Glomerular filtration rate lower than 60 ml / min / 1.73 m², without being in dialysis; Having more than 18 years of age; Not being HIV positive; Not having diagnosis, nor being in treatment of malignant neoplasia; Do not be pregnant or nursing; Moderate periodontitis according to the definition criteria of (2 or more interproximal sites with depth of probing of 5mm or more or 2 or more interproximal sites with loss of insertion of 4mm or more); Present at least 10 teeth present; Negative medical history of any systemic condition that necessitates the use of antimicrobial chemoprophylaxis.
Exclusion criteria
Exclusion criteria: Periodontal treatment in the last 6 months; Pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the present study will be the glomerular filtration rate (GFR) measured in ml / min / 1.73m² based on both creatinine and cystatin C. This will be analyzed through the means and also the change of staging of each participant after treatment periodontal. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in blood concentration of total cholesterol, LDL HDL, glycemia, glacial hemoglobin, triglycerides, creatinine, alkaline phosphatase, vitamin D, C-reactive protein, interleukin and tumor necrosis factor over time. | — |
Countries
Brazil
Contacts
Public ContactAlex Haas
Universidade Federal do Rio Grande do Sul
Outcome results
None listed