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Influence of polymorphisms on the sod3, ppara genes on physical performance and redox balacing of runners supplemented with a single dose of grape juice

Influence of polymorphisms on the sod3, ppara and actn3 genes on oxidative stress, dna methilation and performance in corridors supplemented with red grape juice

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-4d9dmqz
Enrollment
Unknown
Registered
2021-11-12
Start date
2018-01-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Running Athletes Exercise Genetics Nutritional Supplementation

Interventions

47 athletes were tested for the acute effects of supplementation with grape juice or control drink. First the athletes performed a 3,200 meter test on an official athletics track to characterize maxim
G11.427.410.698.277

Sponsors

Ufpb - Universidade Federal da Paraiba
Lead Sponsor
Ufpb - Universidade Federal da Paraiba
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were defined as: athletes should have been training for at least one year with a frequency of at least four weekly sessions and for at least two months without interruption and taking part in competitions regularly. They also should not have any chronic condition or degenerative diseases, did not smoke, and were not using any long-term medication.

Exclusion criteria

Exclusion criteria: Participants should not consume purple grapes or their derivatives often; and/or dietary supplements, vitamins or bioactive substances present in the grape (polyphenols). Athletes who suffered from skeletal muscle injuries, altered dietary habits or had inconsistent training patterns, started using medication or did not perform some of the study experimental procedures were also excluded.

Design outcomes

Primary

MeasureTime frame
Improvement of the performance in athletes in the treadmill running test, after supplementation with 10ml / kg of grape juice.;Significantly higher 10.1% improvement in performance (running time on a treadmill) after supplementation with grape juice compared to the control drink (57.2 ± 17.6 versus 54.0 ± 18.9 minutes, p < 0.02; d = 0.17. 9.0% improvement in performance (running time on a treadmill) in the group with GG + CG genotypes of the SOD3 gene compared to the CC genotype (58.4 ± 18.7 vs 53.8 ± 14.2; 3 , 4 ± 9.7 minutes more, p <0.03; d = 0.70.

Secondary

MeasureTime frame
A slight difference was noted in Total Antioxidant Capacity (TAC), since the CC genotype of the SOD3 gene showed higher TAC values in the post-exercise compared to the baseline and with pre-exercise, but these values were not increased compared to the CG+GG group, respectively. ;The SOD3 and PPARa genes were similar at all times for the other biochemical variables (malondialdehyde (MDA), plasma nitrite (NO), creatine kinase (CK) and lactate dehydrogenase (LDH)

Countries

Brazil

Contacts

Public ContactComitê pesquisa
eticaccs@ccs.ufpb.br+55-083-32167791

Outcome results

None listed

Source: REBEC (via WHO ICTRP)