Ascorbic Acid, wound healing, pain,postoperative
Conditions
Interventions
This is a prospective, analytical, randomized, controlled, triple-blind, crossover (split mouth) clinical trial where the patient is his/her own control. Experimental group: 21 patients who will under
Sponsors
Universidade de Pernambuco
Universidade de Pernambuco
Eligibility
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers who do not continually use medications; both sexes; who are between 18 and 30 years old; that have teeth 38 and 48 in the same position; with indication for removal in an outpatient procedure under local anesthesia
Exclusion criteria
Exclusion criteria: Volunteers who do not agree to participate in the research after reading the Free and Informed Consent Form; presence of pathological lesions such as cysts and/or tumors in the region surrounding or associated with the lower third molars; have any suspected or diagnosed allergy to any of the drugs used in the research; volunteers who did not return for the second surgical procedure, to be performed on the opposite side of the initial surgery; pregnant patients; volunteerswho have vitamin C deficiency and require regular vitamin supplementation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The means of postoperative pain levels are expected to differ between the experimental and control groups. Pain intensity will be assessed using a visual analogue scale (10 centimeters), where zero represents no pain and 10 represents the maximum pain ever felt. The number of rescue pills taken by patients will be recorded after 7 days and will also be one of the parameters for assessing the pain outcome. | — |
Secondary
| Measure | Time frame |
|---|---|
| A significant difference in postoperative healing is expected between the vitamin C group and the placebo group, on the 7th and 21st postoperative days. The Landry tissue repair index, the Löe and Silness gingival index, and the Early wound healing score will be used. Periodontal probing was also performed in the distovestibular and distolingual regions of the lower second molar, with subsequent comparison between the pre- and postoperative measurements. Periodontal probing was measured at three different times: preoperative, on the 7th postoperative day and on the 21st postoperative day;A difference in the improvement of postoperative mouth opening is expected between patients in the control group and the experimental group. To measure the parameters of mandibular trismus, the maximum mouth opening (distance between the upper and lower left central incisor) will be taken using a properly calibrated digital caliper and measured with the results described in millimeters. | — |
Countries
Brazil
Contacts
Public ContactCarolina Aires
Universidade de Pernambuco
Outcome results
None listed