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Effect of green tea and metformin on excess of sugar on the blood of obese individuals with pre-diabetes

Effect of green tea extract and metformin on insulin resistance in obese individuals with pre-diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-4bdwxs
Enrollment
Unknown
Registered
2015-07-25
Start date
2014-08-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, hyperglycemia

Interventions

Experimental groups: A. Green Tea Group: 35 obese patients will consume two capsules containing 500 mg of green tea extract (> 50% polyphenols) per day and two placebo capsules composed of cellulose.
Drug
D02.078.370.141.450
B01.650.940.800.575.100.928.500.500.500

Sponsors

CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Lead Sponsor
Faculdade de Nutricao (FANUT/UFG)
Collaborator

Eligibility

Sex/Gender
Female
Age
20 Years to 59 Years

Inclusion criteria

Inclusion criteria: Obese individuals (fat> 30%) with pre-diabetes, women, aged 20-60 years.

Exclusion criteria

Exclusion criteria: Volunteers with thyroid disorders; diabetes; renal and hepatic diseases; pregnant women; nursing; in hormone replacement; under treatment for weight control; those who are not available to participate in all stages of the study.

Design outcomes

Primary

MeasureTime frame
Changing the parameters ??of glycemic control assessed by fasting plasma glucose through enzymatic colorimetric method and glycated hemoglobin by turbidity method, based on the statement of change in pre- and post- intervention measurements to identify them as risk factors for type 2 diabetes mellitus in this population—

Secondary

MeasureTime frame
Changes in other risk factors for type 2 diabetes: the body composition assessed by densitometry (DEXA) from the realization of a range of at least 2% in pre and post intervention measurements; lipid profile checked the levels of triglycerides, total cholesterol and fractions through enzymatic methods and enzymatic colorimetric from the realization of a range of at least 1% in the pre and post intervention measurements; inflammatory status evaluated by the change in tumor necrosis factor levels, interleukin 6, interleukin 10, leptin, insulin and adiponectin levels being determined by means of a high sensitivity panel to humans (Milliplex, Millipore Corp., Missouri, USA) using Luminex xMAP technology (Multiple Analyte Profiling) which shall be considered an outcome occurred if there is any negative change; antioxidant activities verified by analyzing the antioxidant capacity of plasma and activity of antioxidant enzymes, which will be considered as an outcome occurred if there is any negative change—

Countries

Brazil

Contacts

Public ContactMonallisa;Patrícia Ferreira;Botelho

Faculdade de Nutricao (FANUT/UFG);Faculdade de Nutricao (FANUT/UFG)

mona-alves@hotmail.com;patriciaborges@ufg.br+55 (62) 3209-6270;+55 (62) 3209-6270

Outcome results

None listed

Source: REBEC (via WHO ICTRP)