Effect of treatment with whole Grape Juice along with traditional treatment in patients hospitalized with covid19

Evaluation of Grape Juice treatment on Systemic Inflammation, Oxidative Stress, Autonomic Neuromodulation and the impacts of these variables on the severity of progression of Covid19 (2019 coronavirus disease) in hospitalized patients

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-4bcp54k

Enrollment

Unknown

Registered

2021-09-06

Start date

2020-10-20

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Interventions

The sample was randomly composed according to the admission of patients to the hospital who had a confirmed diagnosis for COVID-19. On admission, after randomization and before the start of interventi

E01.370.225.998.110

G07.203.650.220.500

E07.230.460

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Volunteers of both sexes over 18 years of age who had confirmed COVID-19 disease between October 20, 2020 and February 28, 2021, and who were functionally able to ingest food, in addition to agreeing to participate in the study by signing the Informed Consent Form

Exclusion criteria

Exclusion criteria: Patients who had difficulties in ingesting food during the study, died and/or did not undergo the final tests at hospital discharge, in addition to medical recommendations not to ingest the drink, were excluded from the study.

Design outcomes

Primary

Measure	Time frame
It is expected to find a clinical improvement in patients hospitalized with covid 19 who were supplemented with whole red grape juice, verified by a decrease in systemic inflammation with a reduction in the inflammatory marker PRC (C-reactive protein) and a reduction in oxidant markers.;A decrease in the inflammatory marker CRP (C-reactive protein) was observed in both groups. In the Control Group a reduction of 33.81% was observed, however, in the Grape Juice Group the reduction was 71.64%. There was a small increase in the oxidative marker MPO (myeloperoxidase)	—

Measure

Time frame

It is expected to find a clinical improvement in patients hospitalized with covid 19 who were supplemented with whole red grape juice, verified by a decrease in systemic inflammation with a reduction in the inflammatory marker PRC (C-reactive protein) and a reduction in oxidant markers.;A decrease in the inflammatory marker CRP (C-reactive protein) was observed in both groups. In the Control Group a reduction of 33.81% was observed, however, in the Grape Juice Group the reduction was 71.64%. There was a small increase in the oxidative marker MPO (myeloperoxidase)

—

Secondary

Measure	Time frame
It is expected that, with the reduction of inflammatory and oxidative stress markers, there will be a clinical improvement in hospitalized patients, and, therefore, there will be a decrease in the hospitalization time of these patients;There was a much greater reduction in the inflammatory marker CRP (C-reactive protein) in the grape juice group, causing a shorter hospital stay in these patients around 6.85 days, while the control group remained hospitalized around 9.94 days	—

Measure

Time frame

It is expected that, with the reduction of inflammatory and oxidative stress markers, there will be a clinical improvement in hospitalized patients, and, therefore, there will be a decrease in the hospitalization time of these patients;There was a much greater reduction in the inflammatory marker CRP (C-reactive protein) in the grape juice group, causing a shorter hospital stay in these patients around 6.85 days, while the control group remained hospitalized around 9.94 days

—

Countries

Brazil

Contacts

Public ContactAislan Erick de Sousa

aislanerick1@gmail.com+55 (86) 988347851

Outcome results

None listed

Source: REBEC (via WHO ICTRP)