Sickle cell anemia without crisis
Conditions
Interventions
The general objective of the study was to test the hypothesis that there is a reduction in the intestinal absorption of iron in people with sickle cell anemia and iron overload since the serum concent
SP4.606.635.419.496.912.431
Sponsors
Universidade do Estado do Rio de Janeiro
Instituto Estadual de Hematologia Arthur Siqueira Cavalcanti
Eligibility
Age
3 Years to 59 Years
Inclusion criteria
Inclusion criteria: Children from 2 to 10 years old; adolescents aged 11 to 18 years; adults: from 19 to 59 years old, divided into three groups. In group 1, patients with sickle cell anemia with the SS genotype confirmed by HPLC and who are being followed up at the Hemorio hematology outpatient clinic, with a serum ferritin concentration equal to or greater than 1000 ng/mL; in group 2, patients with sickle cell anemia (SS genotype) confirmed by High Performance Liquid Chromatography (HPLC) and who are followed up at the Hemorio hematology outpatient clinic, with serum ferritin concentration below 1000 ng/mL; in group 3, healthy individuals who do not have sickle cell anemia proven by HPLC
Exclusion criteria
Exclusion criteria: Participants with sickle cell anemia who have been hospitalized and/or received transfusions in the last 15 days prior to the assessment; individuals in the group without sickle cell anemia who have sickle cell trait or other haemoglobinopathies, hematological diseases and/or who use medication for diabetes mellitus and hypo/hyperthyroidism and/or who have serum ferritin less than 10 ng/mL for women and less than 20 ng/mL for men. Pregnant women were also excluded from both groups.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It is expected that there will be a reduction in intestinal iron absorption in people with sickle cell anemia and iron overload, and the rate of iron absorption will be assessed using the stable isotope labeling technique (57Fe). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactMarta dos Reis
Universidade do Estado do Rio de Janeiro
Outcome results
None listed