Periapical Periodontitis
Conditions
Interventions
This research will be conducted in two stages. The first stage consists of a case-control study, followed by a second stage involving a randomized clinical trial (RCT). In the first phase, study parti
Sponsors
Fundação Universidade Federal do Maranhão
Programa de Pós-Graduação em Odontologia - UFMA
Eligibility
Age
22 Years to 25 Years
Inclusion criteria
Inclusion criteria: Individuals aged 22 to 25 years; male and female; with a diagnosis of one or more teeth with asymptomatic apical periodontitis; with daily intake of added sugars above the level recommended by the World Health Organization (WHO) (=10%) in the first phase of the study
Exclusion criteria
Exclusion criteria: Individuals with difficulty changing dietary habits; inability to follow the recommended diet due to religious reasons or disorders of mastication or swallowing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To analyze the biological mechanisms involved in the association between asymptomatic apical periodontitis and cardiovascular risk. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the effect of modifiable cardiovascular risk factors (diet, alcohol consumption, and smoking) on the extent of asymptomatic apical periodontitis in young adult individuals; to evaluate the effect of metabolic cardiovascular risk factors (blood pressure, overweight/obesity, hyperglycemia, and hyperlipidemia) on the extent of asymptomatic apical periodontitis in young adult individuals; to evaluate the effect of systemic inflammatory burden (serum levels of inflammatory biomarkers) on the extent of asymptomatic apical periodontitis in young adult individuals; to evaluate the association between asymptomatic apical periodontitis, altered levels of specific cardiovascular risk biomarkers, and arterial stiffness in young individuals, when common risk factors are included in the analysis; to evaluate the effect of non-surgical endodontic treatment on the systemic expression of inflammatory markers, including specific cardiovascular risk markers, in patients with asymptomatic apical periodontitis; and to evaluate the effect of restricting added sugar consumption on the healing of asymptomatic apical periodontitis following endodontic treatment. | — |
Countries
BR
Contacts
Public ContactSoraia Souza
Universidade Federal do Maranhão
Outcome results
None listed