Heart Defects, Congenital
Conditions
Interventions
The present study is a controlled and randomized clinical trial. Patients considered eligible to participate in the study were randomized by a “blind” collaborator using a random code generator (www.r
respectively. After resting in the supine position for 30 min, a cold pressor test will be applied by immersing the subject's hand in a bucket with ice and water or 1 minute to evaluate hemodynamic an
I02.233.543
Sponsors
Universidade do Estado do Rio de Janeiro
Universidade do Estado do Rio de Janeiro
Eligibility
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Be aged between 40-70 years. For the groups composed of people with cardiovascular impairment: be enrolled in the cardiac rehabilitation service of Hospital Universitário Pedro Hernesto (HUPE)
Exclusion criteria
Exclusion criteria: For groups composed of people with cardiovascular impairment: practice of regular physical exercises (= 3 days/week for 30 min) in the last 6 months; malnutrition; use of antidepressant medication; smoking habit. In addition to the aforementioned criteria, for healthy control subjects, those with a previous or current diagnosis of arterial hypertension; coronary artery disease; heart failure; ischemic disease; pulmonary disease; diabetes mellitus; Chagas disease; tuberculosis; and/or use of antihypertensive medication ill not be considered eligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic and diastolic blood pressure will be measured in the non-dominant arm using a digital sphygmomanometer (Omron HEM - 7113, Kyoto, Japan) positioned around the proximal third of the arm. Data will be collected at rest and every minute during the cold pressure test and PECA. Autonomic modulation will be evaluated through heart rate variability (HRV), obtained by analyzing the RR intervals recorded by a heart rate monitor (Polar V800 XC, Kempele, FIN). The analysis of the data obtained for HRV was performed in the time and frequency domains, using the Kubios HRV program (Version 3.4, Kuopio, Finland). The time domain variables were: mean of RR intervals (RRi), standard deviation of NN intervals (SDNN), square root of successive mean squared differences of adjacent RRi (rMSSD) and percentage number of adjacent RRi pairs differing by more than 50 ms from the previous RRi (pNN50). | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, systolic blood pressure, diastolic blood pressure, mean blood pressure, stroke volume, cardiac output and peripheral vascular resistance will be measured. These variables will be measured using the Finometer PRO device (Finapress Medical Systems, Enschede, NL), which allows continuous non-invasive assessment. Blood lactate will be measured to verify the metabolic stress induced by PECA. For this, the fingertip of the exercised arm will be punctured with an automatic lancet and 0.7 µl of capillary blood sample will be collected during PECA, in minutes 5 and 9. The analyzer used will be the Lactate Plus (Noca BioMedical, Massachusetts, USA ), previously validated, which uses an electrochemical lactate oxidase biosensor to measure lactate concentrations. Habitual physical activity will be assessed using the Baecke questionnaire, which assesses habitual physical activity in the last 12 months, through 8 questions that address in a qualitative-quantitative scale the magnitude of occupational physical activities, physical exercises during leisure time and physical activities. performed in leisure and locomotion. | — |
Countries
Brazil
Contacts
Public ContactJuliana Borges
Universidade do Estado do Rio de Janeiro
Outcome results
None listed