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Effects of aerobic and resistance exercise training on the heart performance and its relationship to genetic alteration in diabetic patients - randomized controlled clinical trial

Combined effects of exercise training on cardiovascular and metabolic performance and its relation to the polymorphism AMPD1 gene in diabetic patients - randomized controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-492q8z
Enrollment
Unknown
Registered
2015-12-02
Start date
2012-08-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus type II

Interventions

The study gathered 40 volunteers with type 2 diabetes aged up to 30-50 years, of both sexes. Block randomization will be performed. Will be 2 groups: control group, n = 20 which receive nutrition lect
Other
I02.233.543
E02.831.387.875

Sponsors

Universidade Federal de São Carlos
Lead Sponsor
Conselho Nacional de Desenvolvimento Cientifico e Tecnológico
Collaborator

Eligibility

Age
30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Volunteers of both genders between 30-65 years;Clinical diagnosis of type 2 diabetes, according to the American Diabetes Association; Clinically stable; Non-practicing physical activity in the last six months, with sort of sedentary, according to the American Heart Association (VO2max: 30.2 ± 4 3 ml/kg/min-1).

Exclusion criteria

Exclusion criteria: Smokers, elitist, in the presence of any diseases of the respiratory system and skeletal muscle, active inflammatory disease, acute or chronic, and evidence of myocardial ischemia and / or cardiovascular pathologies to clinical and / or exercise test.

Design outcomes

Secondary

MeasureTime frame
Improvement of physical capacity, which is measured by oxygen consumption (peak VO2). It is expected after the training period an improvement of cardiorespiratory fitness which will be verified by the maximal oxygen uptake for that cardiopulmonary test will be performed. It is expected an increase of 1.2 ml / kg / min. after the combined physical activity program;The secondary outcome to evaluate the values of VE/VCO2 slope and the linear relationship between oxygen uptake and minute ventilation - OUES after exercise program intervention.

Primary

MeasureTime frame
It is expected improved glycemic control, which will be checked by glycated hemoglobin. It is expected to decrease between pre and post training of approximately 1%. These results are expected after a 3-month intervention period. To assess this outcome biochemical tests involving assessment of glycated hemoglobin, fasting glucose will be performed. Main results (1) demonstrated that a 12-week supervised, individualized, and personalized CART significantly improved (2) glycemic control, (3) body composition, (4) peak VO2, and (4) muscular strength. Additionally, peak VO2 was correlated with HbA1c. ;The primary outcome to evaluate the values of Circulatory power and ventilatory power indices in patients with DM after a short period of combined training exercise program.

Countries

Brazil

Contacts

Public ContactDaniela Bassi

Federal University of Sao Carlos

danibassi26@ig.com.br+5516988222747

Outcome results

None listed

Source: REBEC (via WHO ICTRP)