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Effect of ibuprofen + caffeine administration on the reduction of dental sensitivity from in-office bleaching

Effect of anti-inflammatory administration on the reduction of dental sensitivity from in-office bleaching

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-48c9xt
Enrollment
Unknown
Registered
2018-08-28
Start date
2018-08-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin sensitivity

Interventions

It will be a parallel-type study. Eighty-four patients will be distributed in two groups. Experimental group: forty patients will receive 1 dose of the drug ibuprofen + caffeine, 1 hour before the bl
Drug
Other

Sponsors

Universidade Estadual de Ponta Grossa - UEPG
Lead Sponsor
Universidade Estadual de Ponta Grossa - UEPG
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients will be included who are older than 18 years of age with good oral and general health; have their maxillary anterior teeth free from restorations and carious lesions; with color A2 or darker according to the Classical Vita scale (Vita Zahnfabrik, BadSäckingen, Germany); and to agree with the free and informed consent form.

Exclusion criteria

Exclusion criteria: Patients will be excluded who have already performed dental whitening; pregnant patients or lactating; severe browning (staining by tetracycline; fluorosis or endodontics); people with dental prostheses and orthodontic appliances and any other oral pathology. Patients will be excluded that present changes stomach; heart; kidney and liver problems; diabetes; hypertension or are making continual use of drugs with analgesic and anti-inflammatory.

Design outcomes

Primary

MeasureTime frame
Expected outcome: Number of patients that report spontaneous pain in any moment of the bleaching protocol and up to 48 hours post-bleaching, through self-report. This number will be presented as percentage of patients with tooth sensitivity and will be named absolute risk of tooth sensitivity;Observed outcome: The same expected outcome. No change in the outcome was done.

Secondary

MeasureTime frame
Expected outcome: The intensity of tooth sensitivity will be evaluated through the records made by patients with the use of numerical scales of 5 points (NRS 0-4) and visual analogue scale VAS (0-10). Values are presented as mean and standard deviation for the different evaluated periods (during tooth whitening by 1 h, 1 h to 24 h and 24-48 h post-bleaching);Observed outcome: The same expected outcome. No change in the outcome was done.;Expected outcome: The difference in color between the baseline condition and 1 month post-bleaching will be assessed by Vita Classical and Bleachedguide Vita shade guide as well as with the Vita Easyshade spectrophotometer. The data will be presented as means and standard deviations;Observed outcome: The same expected outcome. No change in the outcome was done.

Countries

Brazil

Contacts

Public ContactPaulo ;Paulo Farago ;Farago

Universidade Estadual de Ponta Grossa - UEPG;Universidade Estadual de Ponta Grossa

pvfarago@gmail.com;pvfarago@gmail.com+55-042-32203741;(42) 32203102

Outcome results

None listed

Source: REBEC (via WHO ICTRP)