Thrombosis biomarkers after varicose vein treatment using foam injection and conventional surgery

Peripheral blood thrombosis biomarkers after great saphenous vein reflux treatment using polidocanol foam chemical ablation and conventional saphenectomy - None: None

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-47pnrf

Enrollment

Unknown

Registered

2019-12-27

Start date

2019-09-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Varicose veins without ulcer or inflamation

Interventions

Chemical ablation group: 35 patients of both sexes, all ethnic groups and aging 18-80 years presenting with lower limbs symptomatic varicose veins with great saphenous vein reflux will be submitted to

Procedure/surgery

C14.907.927

Eligibility

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Symptomatic varicose veins; age 18-80 years; great saphenous veins total or partial reflux in one or both limbs, detected by duplex ultrasound.

Exclusion criteria

Exclusion criteria: Significant active comorbidity; infectious disease (infected ulcer); thrombophilia; previous tromboembolic event; anticoagulant or antiplatelet use; pregnancy; increased cardiovascular risk.

Design outcomes

Primary

Measure	Time frame
Through determination of peripheral blood thrombosis biomarkers: -Thrombin antithrombin complex -D dimers -Trombomodulin -Von Willebrand factor antigen -Soluble P selectin; we expect finding variation between the two therapeutic methods.	—

Secondary

Measure	Time frame
Through application of quality of life scores CIVIQ and Aberdeen, we expect finding variation between the two therapeutic methods. ;Through Doppler ultrasound, we will determine the great saphenous vein post treatment status, which can be classified: -Oclusion -Partial recanalisation without reflux -Partial recanalisation with reflux. -Total recanalisation We expect finding variation between the two therapeutic methods.	—

Measure

Time frame

Through application of quality of life scores CIVIQ and Aberdeen, we expect finding variation between the two therapeutic methods. ;Through Doppler ultrasound, we will determine the great saphenous vein post treatment status, which can be classified: -Oclusion -Partial recanalisation without reflux -Partial recanalisation with reflux. -Total recanalisation We expect finding variation between the two therapeutic methods.

—

Countries

Brazil

Contacts

Public ContactMarcelo Dalio

Universidade de São Paulo - Faculdade de Medicina de Ribeirão Preto

mbdalio@usp.br+55 16 3602 25 93

Outcome results

None listed

Source: REBEC (via WHO ICTRP)