Oxidative Stress
Conditions
Interventions
The groups will be composed of participants with Down Syndrome of both sexes. After being informed about the objectives and the procedures of the study, orally and in writing, the patients who wish to
glycated hemoglobin A1c (HBA1c), lipid profile - (total cholesterol (CLT), LDL-cholesterol, HDL-cholesterol, triglycerides (TG) ), urea (urine), creatinine (CT), thyroid stimulating hormone (TSH), uri
Dietary supplement
D01.875.800.800.850.950
G07.203.300.456
D02.806.250.900
Sponsors
Universidade Federal do Rio Grande do Norte - UFRN
FarmaFórmula Cidade Alta
Eligibility
Age
5 Years to 9 Years
Inclusion criteria
Inclusion criteria: Individuals who agree to participate in the research; as well as those responsible; have ages between 5 and 9 years; are present at the institution during the evaluation period
Exclusion criteria
Exclusion criteria: Participants with antioxidant therapy; diabetics; congenital heart disease, nephropathy; individuals with systemic inflammation and / or severe disease that makes it impossible to perform the study; smoking individuals; those who make use of alcoholic beverages; individuals who are in some type of pharmacological therapy, including vitamins
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of oxidative stress by the increase in antioxidant parameters of glutathione (GSH), glutathione peroxidase (GPx) and superoxide-dismutase (SOD), as well as reduction of Malonaldehyde (MDA) of individuals with Down syndrome supplemented with coenzyme Q10 More zinc sulfate heptahydrate after 90 days of treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected. | — |
Countries
Brazil
Contacts
Public ContactPós Graduação em Ciências Farmacêutica PPgCF
Universidade Federal do Rio Grande do Norte - UFRN
Outcome results
None listed