Eye diseases
Conditions
Interventions
D05.750.078.739.249.500
Administration of nicotine-containing chewing gums (2-mg or 4-mg) or placebo (containing the same texture, taste and appearance as nicotine gums). Thirty participants from the general population will
Study 2- investigation of chromatic contrast sensitivity). All of the participants will participate in this repeated-measures design(placebo, 2-mg or 4-mg). The participants will receive copies of the
Qualified professionals will be available if urgent needs arise. The experimental sessions will have a minimum time of 48 hours and a maximum time of one week.
Behavioural
Other
Sponsors
Universidade Federal da Paraiba
Universidade Federal da Paraiba
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Participants who do not use alcohol (only moderate use ~ 5 weekly doses will be recruited; do not use of psychotropic drugs; do not have Axis I or II disorders (measured by the Mini International Neuropsychiatric Interview ~ MINI). All participants will respond to Fagerstrom Test of Nicotine Dependence (FTND), which measures whether they have nicotine dependence. Demographics will be collected by one of the responsible researchers through a brief anamnesis.
Exclusion criteria
Exclusion criteria: All participants who use alcohol or psychostimulant drugs, known autoimmune disease or AIDS, ophthalmic disorders such as glaucoma or retinopathies will be excluded from the study. In addition, participants who present any neuropsychiatric disorder or disease that affects visual functions will be excluded from the sample. Participants with a family history or presence of depression or anxiety will be screened for further studies. In addition, the presence of additional medications (therapeutic dose or not) will serve as an exclusion criterion since these participants will be part of an additional group, not measured in this work. All participants who for any reason no longer wish to participate in the research will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The existence of effects of nicotine on the visual processing and cognition of non-smoking adults. After chewing gum is administered, an effect (positive or negative) will be characterized by an increase or decrease in the results of the tests used (cut-off points were available in previous laboratory studies). Participants will be assessed by applying the Metropsis and Cambridge Color Test. Significant differences (p <.05) will be observed in relation to the three conditions used. It is believed that the greater the amount of nicotine ingested may result in a greater difference. | — |
Secondary
| Measure | Time frame |
|---|---|
| Aspects related to the safety and tolerability profile of nicotine intake employed in healthy non-smoking adults. Investigate whether sex and body mass index have an impact on results after ingesting nicotine gums. | — |
Countries
Brazil
Contacts
Public ContactThiago Fernandes
Universidade Federal da Paraiba
Outcome results
None listed