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Concentration of Brain-Related Proteins in the blood of adults with Autism and their relationship with neuropsychological tests

Evaluation of blood concentration of BDNF and proBDNF in adult patients diagnosed with Autism Spectrum Disorder and its correlation with neuropsychological assessment parameters in a brazilian population

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-46dvfxf
Enrollment
Unknown
Registered
2024-10-09
Start date
2024-09-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Childhood autism

Interventions

This is an observational, cross-sectional study with a group of 50 participants, 25 adults diagnosed with Autism Spectrum Disorder (ASD) and 25 adults without the diagnosis of ASD (control group). Par
V03.175.500

Sponsors

Universidade Federal de Santa Catarina
Lead Sponsor
Universidade Federal de Santa Catarina
Collaborator

Eligibility

Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adults aged between 18 and 65 years; previous diagnosis of Autism Spectrum Disorder (ASD) confirmed by a psychiatrist (for the ASD group);residents in Brazil; ability to provide informed consent, or having a legal representative capable of doing so in case of incapacity; availability to complete the Wechsler Adult Intelligence Scale, Beck Depression Inventory - Second Edition, Beck Anxiety Inventory, Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised instruments; willingness to provide biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis; both genders

Exclusion criteria

Exclusion criteria: Severe neurological or psychiatric conditions, such as schizophrenia or severe bipolar disorder; severe sensory or motor deficits; adults unable to consent and without a legal representative; ongoing medication treatments that may significantly influence behavior or cognitive responses; medical conditions that prevent safe collection of biological samples for Brain-Derived Neurotrophic Factor (BDNF) analysis

Design outcomes

Primary

MeasureTime frame
A mean difference is expected in the concentration levels of brain-derived neurotrophic factor (BDNF) and in the concentration levels of precursor brain-derived neurotrophic factor (proBDNF)—

Secondary

MeasureTime frame
A significant relationship is expected between neurotrophic factor levels and performance on neuropsychological assessments—

Countries

Brazil

Contacts

Public ContactBaltasar Brange

Universidade Federal de Santa Catarina

baltasar.brange@posgrad.ufsc.br+55-48-37216094

Outcome results

None listed

Source: REBEC (via WHO ICTRP)