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Root canal treatment x retreatment: microbial profile and signs and symptoms

Primary X secondary endodontic infections: microbial and profile, endotoxins and lipoteicoic acid levels

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-45wjx4
Enrollment
Unknown
Registered
2018-08-09
Start date
2017-06-12
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic apical periodontitis

Interventions

Sixty unirradicular teeth are going to be selected from patients with endodontic infection, being thirty with primary endodontic infection (GI) and thirty with secondary endodontic infection (GII). Si
Other
C01.539.392.433
D23.946.123.329
H01.158.273.540
E06.397

Sponsors

ICT - Universidade Estadual Paulista Júlio de Mesquita Filho
Lead Sponsor
Fundação de Amparo à Pesquisa do Estado de São Paulo
Collaborator

Eligibility

Age
21 Years to 60 Years

Inclusion criteria

Inclusion criteria: Unirradicular tooth of patients requiring endodontic treatment; teeth with pulp necrosis and presence of periapical lesion; need for endodontic retreatment; age range from 21 to 60 years of age, favorable health conditions, local and systemic; unirradicular teeth with unsatisfactory prior endodontic treatment performed 3 years ago or more; presence of periapical lesion visible

Exclusion criteria

Exclusion criteria: Periodontal disease; root fracture, exposure of the pulp chamber to the mouth; patients who used antifungals and antibiotics in the period of three months before the endodontic treatment; impossibility of absolute isolation were not included

Design outcomes

Primary

MeasureTime frame
Verification of the initial profile of primary and secondary endodontic infections;Comparison of the initial profile of primary and secondary endodontic infections—

Secondary

MeasureTime frame
Microbial load and microbiological identification, by microbial culture and Checkerboard test and statistical analysis; Quantification of endotoxin (UE / mL) and lipoteichoic acid (LTA) levels, by LAL assay and ELISA and statistical analysis;(CFU / mL) and microbiological profile with clinical signs and symptoms and periapical lesion volume (mm³), using concomitant computed tomography (CBCT); by laboratory, signs and symptons submitted to statistical analysis;Relation of endotoxin and LTA levels with clinical signs and symptoms and volume of CBCT lesions, by laboratory, signs and symptoms and volume of the lesion analysis submitted to statistical analysis—

Countries

Brazil

Contacts

Public ContactFelipe Machado

ICT - Universidade Estadual Paulista Júlio de Mesquita Filho

felipepaivamachado@gmail.com+55(12)982176442

Outcome results

None listed

Source: REBEC (via WHO ICTRP)