Spectroscopy applied to the diagnosis of Autism Spectrum Disorder with saliva analysis

FT-IR Spectroscopy applied in the diagnosis of Autism Spectrum Disorder with analysis of saliva and perinatal factors associated with the disorder

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

REBEC

Registry ID

RBR-45mf7b2

Enrollment

250

Registered

2026-06-25

Start date

2025-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorder Neurodevelopmental Disorders

Interventions

This is an observational, cross-sectional, analytical, and comparative study with a quantitative approach focused on evaluating the effectiveness of Fourier Transform Infrared Spectroscopy as a tool f

Subgroup B: 9 years to 17 years and 11 months, comprising 100 participants

and Subgroup C: 18 years to 50 years, comprising 50 participants. Since this is a non-randomized study, no participant randomization process will be performed. The study will be open-label and without

Eligibility

Age

4 Years to 50 Years

Inclusion criteria

Inclusion criteria: Participants aged between 4 and 50 years; both sexes; with a previous diagnosis of Autism Spectrum Disorder - ASD (study group) or neurotypical individuals (control group); absence of intraoral lesions; parents and/or legal guardians aware of and in agreement with the research objectives through signing the Informed Consent Form and the Informed Assent Form

Exclusion criteria

Exclusion criteria: Participants who do not cooperate or do not adequately allow sample collection; who do not agree to participate in the research; individuals with intraoral lesions

Design outcomes

Primary

Measure	Time frame
An effective, safe, low-cost, and non-invasive protocol for the rapid and painless diagnosis of Autism Spectrum Disorder (ASD) is expected to be established, verified through an interdisciplinary and translational approach based on the analysis of the results obtained during the application of the protocol. The outcome will be assessed according to the diagnostic effectiveness observed, considering parameters such as the ability to discriminate individuals with ASD from control groups, the reproducibility of the obtained results, and the agreement between the protocol findings and previously established clinical diagnostic criteria	—

Measure

Time frame

An effective, safe, low-cost, and non-invasive protocol for the rapid and painless diagnosis of Autism Spectrum Disorder (ASD) is expected to be established, verified through an interdisciplinary and translational approach based on the analysis of the results obtained during the application of the protocol. The outcome will be assessed according to the diagnostic effectiveness observed, considering parameters such as the ability to discriminate individuals with ASD from control groups, the reproducibility of the obtained results, and the agreement between the protocol findings and previously established clinical diagnostic criteria

—

Secondary

Measure	Time frame
No secondary outcomes are expected	—

Countries

Contacts

Public ContactEmilia;Geraldo Arisawa;De Abreu

Universidade do Vale do Paraíba ;Universidade do Vale do Paraíba

mirela@univap.br;deabreumagno@gmail.com+55-12-39471103;+55-12-39471103

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026