Dyspnea
Conditions
Interventions
This is a two-arm, double-blind, multicenter randomized controlled clinical study. Fifty-two patients will be randomized to two groups. In the intervention group, patients will participate in a 10-wee
G11.427.410.698.277
Sponsors
Universidade Federal do Rio Grande do Norte - UFRN
Universidade Federal do Ceará
Eligibility
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Men and women. Age between 18-75 years. Laboratory diagnosis of COVID-19 by RT-PCR, SWAB or serology = 3 months ago. Fatigue or dyspnea associated with post-COVID syndrome in the last week. Access to a smartphone
Exclusion criteria
Exclusion criteria: Severe functional limitation. Participation in a physical exercise program in the last three months. Osteomioarticular problems that prevent physical tests and the training program from being carried out or important osteomyoarticular events during the study, such as muscle injuries that cause exercise limitations. High alcohol consumption, ie, > 14 drinks per week. Smoking. Morbid obesity. Uncontrolled hypertension. Diabetes using insulin or decompensated. Incidence of cardiovascular or pulmonary events during the study. History of major cardiovascular diseases or events. Chronic limiting lung disease. Chronic kidney disease requiring dialysis. Cancer requiring treatment within the last two years. Medical diagnosis of progressive neurological diseases. Illiteracy. Incomplete vaccination schedule against COVID-19
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in functional capacity after 10 weeks of physical training through increased cardiorespiratory capacity and lower limb strength, assessed by the six-minute walk test and the 30-second sit-to-stand test, respectively, through statistically confirmed increase significant (p<0.05) between pre- and post-intervention measures compared to the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in cardiorespiratory demand at submaximal effort after 10 weeks of physical training assessed by heart rate during the Shuttle Walking Test, by confirming a statistically significant decrease (p<0.05) between pre- and post-intervention measurements compared to the control group.;Improvement in agility and dynamic balance after 10 weeks of physical training evaluated by time in the Timed Up and Go test, through confirmation of a statistically significant decrease (p<0.05) between pre- and post-intervention measures in relation to the control group.;Improvement in the degree of self-reported functional capacity after 10 weeks of physical training assessed by the Post-COVID-19 Functional Status scale, through confirmation of a statistically significant decrease (p<0.05) between pre- and post-intervention measures in relation to control group.;Increase in time in physical activity after 10 weeks of physical training assessed by accelerometry, through confirmation of a statistically significant increase (p<0.05) between pre- and post-intervention measurements in relation to the control group.;Improvement of physical symptoms of long COVID after 10 weeks of physical training through reduction of fatigue, dyspnea and post-exertional malaise, assessed, respectively, by scores on the Chalder Scale, Modified MRC Dyspnea Scale and Malaise Questionnaire be post-dePaul effort, by confirming the statistically significant reduction (p<0.05) between pre- and post-intervention measurements compared to the control group.;Improved cardiovascular health after 10 weeks of physical training through the reduction of blood pressure and arterial stiffness and increased autonomic modulation, assessed, respectively, by an oscillometric blood pressure meter, by the Dyna-MAPA AOP equipment and heart rate variability, through confirmation of a statistically significant difference (p<0.05) between pre- and post-intervention measurements compared to the control group.;Improvement of sl | — |
Countries
Brazil
Contacts
Public ContactEduardo Costa
Universidade Federal do Rio Grande do Norte - UFRN
Outcome results
None listed