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Effect of 17% Glycolic Acid in Primary Endodontic Treatment: Randomized Clinical Trial

Effect of 17% Glycolic Acid on Periapical Healing in Primary Endodontic Treatment: Randomized Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-44q9k6q
Enrollment
Unknown
Registered
2023-10-17
Start date
2022-07-31
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis

Interventions

This is a four-arm, double-blind, randomized controlled clinical study. A total of 200 people who meet the eligibility criteria will be probabilistically allocated to one of four intervention groups u
Group 2: 50 endodontics performed with a reciprocating system and final irrigation with 17% glycolic acid
Group 3: 50 endodontics performed with a rotary system and final irrigation with 17% Edta
Group 4: 50 endodontics performed with a rotary system and final irrigation with 17% glycolic acid

Sponsors

Universidade de Passo Fundo
Lead Sponsor
Universidade de Passo Fundo
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy volunteers; both genders; non smokers; previously initiated endodontic therapy

Exclusion criteria

Exclusion criteria: Smoking volunteers; history of alcohol or drug abuse; diagnoses of cardiac, renal, gastrointestinal, hepatic, pulmonary, neurological, psychiatric, hematological or metabolic pathologies, endodontic retreatment, root resorption, immature/open apex, root canal where patency of the apical foramen cannot be established

Design outcomes

Primary

MeasureTime frame
To evaluate the response to the postoperative pain level of primary endodontic treatment with the visual analogue scale (VAS) method used to verify the expected outcome of pain or no postoperative pain in 24 hours, 48 hours and 7 days in the four study groups after completion of 200 endodontic treatments. It is expected to find in the groups with glycolic acid irrigating solution a reduction or no reports of postoperative pain in these 2 groups, based on the observation of a variation of at least 5% in post-intervention measurements at 24 hours, 48 hours and 7 days

Secondary

MeasureTime frame
No secondary outcomes are expected

Countries

Brazil

Contacts

Public ContactPaola Figueiredo

Univercidade de Passo Fundo

paolafigui@hotmail.com55 54 999376360

Outcome results

None listed

Source: REBEC (via WHO ICTRP)