women's health
Conditions
Interventions
Thirty two women were submitted to a familiarization session and three experimental sessions at different stages of the menstrual cycle. In the familiarization session, they were submitted to the asse
to the assessment instruments: Epworth Sleepiness Scale, Profile of Mood States and Anxiety Inventory (State)
and, then, the recording of electroencephalography, electrooculogram, electromyography and audio during the application of the following experimental protocols: Finger Tapping Test (simple and sequent
E01.370.376.300.294
E05.200.998.110
E01.370.405.255
G11.427.700
E01.370.405.265
Sponsors
Instituto do Cérebro/Universidade Federal do Rio Grande do Norte
Instituto do Cérebro/Universidade Federal do Rio Grande do Norte
Eligibility
Sex/Gender
Female
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Age between eighteen and thirty years years old; regular menstrual cycle for women between twenty two and thirty five days for at least six months; right handed confirmed by the Edinburgh Lateral Dominance Inventory; not using hormonal contraceptive agents for at least six months; having no history of neurological or psychiatric illness; not using psychotropic drugs; primary hearing or visual impairment that cannot be improved with corrective lenses or hearing aids.
Exclusion criteria
Exclusion criteria: Having a progesterone level less than ten nmol per liter on any day of the luteal phase reporting a period of the regular cycle as it is an indication of the lack of an ovulatory cycle; pregnancy; score on the Mini Mental State Examination scale below twenty four or twenty five points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Executive control of movement inhibition is greater in the luteal phase (with high levels of progesterone) when compared to the menstrual and follicular phases (with low levels of progesterone). Executive control will be investigated by the event-related synchronization of the electroencephalography alpha and beta frequency bands on the frontal and central regions during the execution of two variations of the Go/No Go Test. The increase in alpha and beta synchronization is associated with movement inhibition. The go/no go paradigm centered on stimulus 2 (S2) and centered on stimulus 1 (S1) were applied to test this outcome. In the S2-centered paradigm, two sound stimuli were presented (S1 and S2). S1 was a bass beep indicating attention and S2 could be a bass beep indicating that the wrist extension movement should be performed as soon as possible or treble beep, indicating that no movement should be performed. The definition “centered on S2” means that it was only possible at the second beep to identify whether the movement should be performed or not. The synchronization of alpha and beta over the frontal and central regions immediately after the treble S2 (command to inhibit movement) will be used as a measure of movement inhibition in the S2-centered paradigm. In the S1-centered paradigm, two sound stimuli (S1 and S2) of the same tone were presented. When both beeps were bass, the participants performed the wrist extension movement as quickly as possible after S2. When both beeps were treble, the participants did not perform any movement. The definition “centered on S1” means that in the first beep it was possible to identify whether the movement should be performed or not. The synchronization of alpha and beta over the frontal regions immediately after the treble S1 (command to inhibit movement) will be used as a measure of movement inhibition in the S1-centered paradigm. ;The motor response time to a sound stimulus will be shorter in the follicular phase than i | — |
Secondary
| Measure | Time frame |
|---|---|
| The activity in the sensory motor region measured by the desynchronization of the mu rhythm (mu-alpha: 8-12Hz and mu-beta: 15-30 Hz) of electroencephalography varies according to blood levels of estradiol and progesterone. The desynchronization of the mu rhythm correlates positively with the blood concentration of estradiol in the follicular phase (high concentration of estradiol) and negatively with the blood concentration of progesterone in the luteal phase (high concentration of progesterone), or even, with the progesterone / estradiol ratio in the luteal phase (high concentration of progesterone and estradiol). The participants underwent blood collection for estrogen and progesterone measurement and the kinesthetic motor imaging and action observation protocols that generate the mu rhythm over the central regions of electroencephalography. All of these procedures were performed in the three phases of the menstrual cycle (menstrual, follicular and luteal).;The desynchronization in the alpha and beta frequency bands in the frontal and parietal regions of the electroencephalography correlates positively with the blood concentration of estradiol in the follicular phase (high concentration of estradiol) and negatively with the blood concentration of progesterone in the luteal phase (high concentration of progesterone ), or even, with the progesterone / estradiol ratio in the luteal phase (high concentration of progesterone and estradiol). The participants underwent blood collection for estrogen and progesterone measurement and the kinesthetic motor imaging and action observation protocols that generate the mu rhythm over the central regions of electroencephalography. All of these procedures were performed in the three phases of the menstrual cycle (menstrual, follicular and luteal).;Asymmetry in manual skill is predictive of asymmetry in brain interhemispheric activity. Asymmetry in manual skill will be defined as the number of finger taps during the simple and seque | — |
Countries
Brazil
Contacts
Public ContactRafaela;Maria Bernardete Souza;Sousa
;
Outcome results
None listed