Hypertension
Conditions
Interventions
This is a randomized, single-center, parallel-group clinical trial
thirty participants of both sexes, aged between forty-five and sixty-four years, with a diagnosis of early-onset Systemic arterial hypertension, before fifty-five years of age, under treatment for the
after completion of the baseline assessments, eligible participants will be randomly allocated into two groups in a one-to-one ratio, with fifteen participants assigned to the intervention group and f
the study will include masking of the researchers responsible for outcome assessments and analyses
all participants will undergo a baseline assessment consisting of two laboratory visits and will be instructed beforehand to avoid caffeine and alcohol consumption in the previous twelve hours and to
during the first visit, after signing the Informed Consent Form, participants will complete the International Physical Activity Questionnaire and undergo the Montreal Cognitive Assessment to confirm e
during the second visit, performed after a fasting period of six to eight hours, blood samples will be collected, anthropometric measurements will be obtained, and assessments of global cerebral blood
Sponsors
Universidade Federal de Santa Catarina
Universidade Federal de Santa Catarina
Eligibility
Age
45 Years to 64 Years
Inclusion criteria
Inclusion criteria: Individuals of both sexes; age between forty-five and sixty-four years; diagnosis of early-onset systemic arterial hypertension before fifty-five years of age; undergoing treatment for systemic arterial hypertension; presence of mild to moderate cognitive impairment assessed by the Montreal Cognitive Assessment
Exclusion criteria
Exclusion criteria: Individuals with Systemic arterial hypertension stage two, defined by systolic blood pressure equal to or higher than one hundred and sixty millimeters of mercury and or diastolic blood pressure equal to or higher than one hundred millimeters of mercury; presence of severe cognitive impairment or diagnosis of dementia; speech impairment that limits or prevents communication; diagnosis of severe untreated mental disorder; history of severe cardiac diseases; abnormal twelve-lead electrocardiogram at rest or during physical exertion; contraindication to physical exercise indicated by a cardiologist; presence of secondary hypertension; evidence of target organ dysfunction, including kidneys and retina; grade two obesity; presence of severe cardiometabolic diseases; current participation in a structured physical training program; female participants with premature menopause, before forty years of age, or induced menopause
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find an improvement in the cognitive performance of hypertensive people with mild to moderate cognitive impairment after the intervention with high-intensity interval training, measured using the Montreal Cognitive Assessment instrument, applied at the beginning and at the end of the intervention (after 12 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| A reduction in arterial stiffness is expected in participants undergoing high-intensity interval training, assessed by carotid-femoral pulse wave velocity, measured at the beginning and end of the intervention;A reduction in arterial stiffness is expected in participants undergoing high-intensity interval training, assessed by carotid-femoral pulse wave velocity, measured at the beginning and end of the intervention;Improvements in heart rate variability, measured at rest with a short-term electrocardiogram recording, are expected before and after the 12-week intervention period with high-intensity interval training;A reduction in resting systolic and diastolic blood pressure is expected after 12 weeks of high-intensity interval training, compared to baseline values;An increase in serum levels of brain-derived neurotrophic factor is expected after high-intensity interval training, measured through blood samples collected before and after 12 weeks of training;An increase in serum irisin levels is expected in participants undergoing high-intensity interval training, measured by laboratory analysis of blood collected at the beginning and end of the intervention;It is expected to find an association between cognitive performance and the measured physiological parameters (cerebral blood flow, arterial stiffness, heart rate variability, blood pressure, serum levels of brain-derived neurotrophic factor and irisin), evaluated by statistical correlation and regression tests | — |
Countries
BR
Contacts
Public ContactJessica Martins
Universidade Federal de Santa Catarina
Outcome results
None listed