Coronaviruses infections
Conditions
Interventions
Sixty individuals with coronavirus infection who meet the inclusion criteria for the study will receive standard intensive care and organic support therapy, as per clinical assessment (eg oxygen thera
Drug
Sponsors
Victor Côrtes Pourchet de Carvalho
Hospital Niterói D´Or
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: COVID-19 disease with more than seven (7) days of symptoms plus two of the following criteria: 1- Fever (axillary temperature greater than or equal to 38 degrees centigrade) 2- D-dimer greater than 1000 or elevated PCR-t or IL-6. 3- Ventilatory deterioration or gas exchange or need for ventilatory support (non-invasive or mechanical ventilation)
Exclusion criteria
Exclusion criteria: Primary or secondary immunodeficiency. Use of immunosuppressive drugs. Under 18 years old. Pregnancy. Symptoms of less than seven (7) days. Absence of respiratory symptoms. End-of-life care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the reduction of in-hospital mortality in D28 by 10% before and after intervention using a non-parametric test | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate by means of a non-parametric test the increase with the intervention of at least 5 days of survival without mechanical ventilation (that is, days without ventilation) until D28. Days without ventilation are defined as the number of "days alive" and "free" from mechanical ventilation from the day of analysis to day 28th;Assess the reduction of the need for hemodialysis by at least 20% up to D28 before and after intervention by means of a non-parametric test | — |
Countries
Brazil
Contacts
Public ContactVictor de Carvalho
Hospital Universitário Antônio Pedro
Outcome results
None listed