Cardiovascular diseases, aging, sarcopenia, inflammation, body composition, diet, muscle strengtgh, cognition, renal function, quality of life, vascular stiffness, autonomic nervous system, aerobic capacity.
Conditions
Interventions
We will have two intervention groups: the physical training group(n:20) and the control group(n:20). The training group will perform 16 weeks of combined training (strength training plus aerobic trai
followed by continuous walking and/or running from 40% to 60% of VO2 reserve for 50min. All training sessions will be held in the Integrated Laboratory of the Faculty of Physical Education, UNICAMP (L
Other
E02.779.483.875
G11.427.590.530.698.277
E02.779.483
Sponsors
Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas
Programa de Pós-Graduação em /gerontologia, Faculdade de Ciências Médicas, UNICAMP
Eligibility
Age
50 Years to 110 Years
Inclusion criteria
Inclusion criteria: Individuals from both sexes; non-active (frequency of regular physical activity less than two sessions per week); Did not participate in any regular training program over the last 6 months preceding the beginning of the experiment; to be normotensive, or grade 1 (systolic blood pressure: 140 to 149 mmHg or diastolic blood pressure: 90 to 99 mmHg), or 2 (systolic blood pressure 160 to 169 mmHg or diastolic blood pressure: 100 to 109 mmHg) of controlled hypertension (according to the medical report of the participants); have clinical evaluation report carried out by a physician (general physical examination, cardiological and clinical exercise testing) authorizing the practice of physical activity.
Exclusion criteria
Exclusion criteria: Obesity greater than grade 2 (body mass index up to 35); coronary artery disease, diabetes mellitus insulin-dependent; chronic obstructive pulmonary disease; limiting osteoarticular disease; peripheral vascular disease; smokers; in use of medications that may interfere with physiological responses to tests, such as beta-blockers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The outcomes will be considered effective if it was observed an interaction between group and time (any moment measured compared to pre intervention moment) with p-value smaller than 0.05. Blood pressure, in mmHg, measured by finger photopletismography (Finometer). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure variability analysed at Cardioseries Softare,by the standar deviation of the mean of five minutes recording, evaluated monthly along 16 weeks. Cardiac autonomic modulation measured by heart rate record in heart rate monitor (POLAR) and analysis of heart rate variability using specific software (Kubios), with time (RRi, RMSSD e SDNN, in ms, and pNN50, in %) and frequency (LF, HF, VLF, LF/HF, TP, in ms2 and n.u.) domain data, evaluated monthly along 16 weeks. Analysis of the following blood markers: interleukins (IL-6 and IL-10, in pg/ml), adipokines (Adiponectin, in µg/mL, and leptina, in ng/mL), tumor necrosis factor alfa (pg/ml), C-reactive protein (mg/L), oxidative stress markers (TBARS, in nmol/ml, e total oxidant capacity, in mmol ET/L), brain-derived neurotrophic factor (pg/ml), vascular endothelial growth factor (pg/ml), profile lipid (TG, CT, HDL, LDL, in mg/dL), glucose (mg/dL), insulin (µIU/ml), and tissue remodeling markers as extracellular matrix metalloproteinases 9 (pg/ml) and tissue inhibitor of metalloproteinases 1(pg/ml). Evaluated monthly along 16 weeks. Body composition, including overall fat mass and overall lean body mass percent, measured in plethysmograph (BOD POD) and thickness of the vastus lateralis and biceps measuredby ultrasound (Nano-Max Sleep Site), in mm, evaluated monthly along 16 weeks. Maximum strength of the lower limbs measured in isokinetic dynamometer (BIODEX), through rate force development, in ms, before, after 8 and 16 weeks of intervention. Aerobic capacity measured by gas analysis (CPX Medical Graphics) during maximal exercise test on treadmill, generating the maximamum oxygen consumption, in ml/Kg/min., evaluated before, after 8 and 16 weeks of intervention. Electrical activity, of the vastus and lateral. measured by electromyography (Biopac System), evaluated before, after 8 and 16 weeks of intervention. Assessment of functional capacity through the tests: balance (Berg Scale), sitting and rising | — |
Countries
Brazil
Contacts
Public ContactMara Patrícia Mikahil
Faculdade de Educação Física, Laboratório de Fisiologia do Exercício, Universidade Estadual de Campinas
Outcome results
None listed