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Effects of mild versus moderate training in patients with heart failure.

Comparison of the effects of mild versus moderate aerobic training on the inflammatory markers, on oxidative stress and quality of life, in patients with chronic heart failure – a randomized clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-3ypm3f
Enrollment
Unknown
Registered
2011-07-18
Start date
2011-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure, inflammation, oxidative stress

Interventions

Two training protocols isocaloric: ARM 1: physical training of moderate intensity, performed on a treadmill, in heart rate corresponding to 60% of VO2 peak, lasting 30 minutes, 3 times per week, for 1
other
E02.831.387

Sponsors

Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG
Lead Sponsor
Ambulatório de Insuficiência Cardíaca - UFMG
Collaborator
Fundação de Amparo à Pesquisa do Estado de Minas Gerais - Fapemig
Collaborator
Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq
Collaborator

Eligibility

Age
25 Years to 59 Years

Inclusion criteria

Inclusion criteria: Patients with diagnosis of heart failure for at least six months, clinically stable for at least two months before this study. Left ventricular ejection fraction < 45%. Aging between 25 and 59 years old. Body mass index (BMI) < 30 kg/m2. Stage C of the guidelines from the American College of Cardiology and American Heart Association (2005). Classes I to III from the New York Heart Association (NYHA). Sedentary, as defined by American College of Sports Medicine (2007).

Exclusion criteria

Exclusion criteria: User of cardiac pacemaker. Inflammatory diseases in acute phase; Renal insufficiency. Orthopedic or neurological impairments which limit the exercise performance. History of respiratory disease, unstable angina, uncontrolled arrhythmias or peripheral obstructive arterial disease.

Design outcomes

Primary

MeasureTime frame
Inflammatory markers: interleukin-6 (IL-6) and soluble tumor necrosis factor alpha receptor-1 (sTNFR1), measured by ELISA method.;Oxidative stress: malondialdehyde, enzymes superoxide dismutase, catalase and glutathione peroxidase, by enzymatic methods.;Quality of life (scores of the Minnesota Living with Heart Failure Questionnaire).—

Secondary

MeasureTime frame
Results of cardiopulmonary exercise test: peak oxygen uptake (VO2peak), oxygen pulse (VO2/HR), anaerobic threshold (AT), markers of ventilatory efficiency (eg, the VE/VCO2 slope and oxygen uptake efficiency slope - OUES and exercise oscillatory ventilation - EOV).;Six-minute walk test (distance).—

Countries

Brazil

Contacts

Public ContactGiane;Dayane Ribeiro-Samora;Montemezzo

Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG;Escola de Educação Física, Fisioterapia e Terapia Ocupacional - UFMG

gribeirosamora@gmail.com;daymontemezzo@yahoo.com.br+55 31 34094777;+55 31 34094777

Outcome results

None listed

Source: REBEC (via WHO ICTRP)