hernia inguinal, hidrocele
Conditions
Interventions
Experimental groups: (1) 41 patients undergoing surgery under general anesthesia with tracheal intubation and tracheal tubes filled with 0.5% alkalinized lidocaine solution. (2) 41 patients undergoing
Device
Sponsors
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Eligibility
Age
3 Years to 13 Years
Inclusion criteria
Inclusion criteria: Children undergoing general anesthesia; aged between 3 and 13 years; both genders; physical status 1 or 2 according to American Society of Anesthesiologists; minor or medium level surgery
Exclusion criteria
Exclusion criteria: Oropharyngeal and neck malformations and distortions; patients who had already been intubated or tracheostomised; previous presence of stridor or dysphonia; laryngeal or oropharyngeal illness or surgery; requirement for the introduction of a nasogastric or orogastric tube; more than two attempts at tracheal intubation; use of corticosteroids during the perioperative period; the use of local anaesthetic agents administered through a route other than that used to fill the tracheal tube cuffs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the occurrence of sore throat in postoperative period evaluated by face pain scale, ranging from 0 (no pain) to 10 (maximum pain) and recorded as percentage of occurrence;Outcome evaluated: Sore throat at the post anesthesia care unit (values are % of occurrence): Group Air (control): 12.2%; Group Normal saline: 12.2%; Group 0.5% Alkalinized lidocaine: 2.4%; Group 1% Alkalinized lidocaine: 2.4% (qui-square test, p = 0.12). Sore throat 8 hours after tracheal extubation (values are % of occurrence): Group Air (control): 22.0%; Group Normal saline: 9.8%; Group 0.5% Alkalinized lidocaine: 4.8%; Group 1% Alkalinized lidocaine: 2.4% (qui-square test, p = 0.015). Then, pairwise comparison performed: Group Air vs. Group 0.5% Alkalinized lidocaine, p 0.05. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of plasma levels of lidocaine, by blood sample collected 30 minutes after tracheal intubation;Outcome evaluated: Plasma lidocaine concentration. Values are mean and standard deviation, between parentheses, and are expressed as ng/dl: Group 0.5% Alkalinized lidocaine: 48.4 (53.7) Group 1% Alkalinized lidocaine: 77.4 (217.61) p = 0.56 | — |
Countries
Brazil
Contacts
Public ContactPaulo do Nascimento Junior
Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP
Outcome results
None listed