Chronic Obstructive Pulmonary Disease
Conditions
Interventions
his study is a clinical trial with a quasi-experimental design. Single intervention group: 31 patients received in the Emergency Department of the Pronto Socorro de Pelotas in Acute Respiratory Failur
during application of Non-Invasive Ventilation at 30 minutes, 1 hour, 1 hour and 30 minutes, 2 hours
and 1 hour after completion of the protocol. For Chronic Obstructive Pulmonary Disease patients, a pressure-support ventilation mode will be used with expiratory pressure between 5 and 8 centimeters o
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Sponsors
Escola Superior de Educação Física da Universidade Federal de Pelotas
Faculdade de Medicina da Universidade Federal de Pelotas
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients of both sexes, aged 18 years or older with no upper age limit; admitted to the Emergency Department of the Pelotas Emergency Hospital due to Acute Respiratory Failure secondary to Chronic Obstructive Pulmonary Disease or cardiogenic Acute Pulmonary Edema; between January 2024 and August 2024; who were eligible for noninvasive ventilation
Exclusion criteria
Exclusion criteria: Acute Respiratory Failure from causes other than Acute Pulmonary Edema and Chronic Obstructive Pulmonary Disease; Contraindication to Non-Invasive Ventilation, such as Refractory Hypoxemia; Glasgow Coma Scale score below 8; Agitation; Patient Refusal; Hemodynamic Instability with Systolic Blood Pressure below 90 millimeters of mercury; Complex Arrhythmias; Acute Myocardial Infarction; Upper Airway Obstruction; Facial Trauma; Ineffective Cough; Inability to Swallow; Intractable Vomiting; Significant Abdominal Distension; Upper Gastrointestinal Bleeding; Undrained Pneumothorax; Post-operative Status after Surgery of the Upper Airway; Esophagus, or Face; Severe Respiratory Acidosis requiring Immediate Intubatio
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ROX Index below 4.88 is expected to be an effective short-term predictor of Non-nvasive Ventilation failure, measured using the formula: Peripheral Oxygen Saturation / Fraction of Inspired Oxygen / Respiratory Rate. Data will be collected at patient admission, during Non-invasive Ventilation use at 30 minutes, 1 hour, 1 hour and 30 minutes, 2 hours, and 1 hour after the end of the intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that after two hours of applying the Non-invasive ventilation protocol, patients will show an increase in ROX Index values of at least 20 percent for partial reversals and at least 30 percent for total reversals of Acute Respiratory Failure;It is expected that 100 percent of the patients who experience failure during Non-invasive ventilation will have a ROX Index below 4.88 | — |
Countries
Brazil
Contacts
Public ContactNathália Monteiro
Instituto de Biologia Universidade Federal de Pelotas
Outcome results
None listed