Ventilator-Induced Lung Injury
Conditions
Interventions
A single-center, retrospective observational study, following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) model, carried out in the intensive care unit of a terti
Sponsors
instituto de biofisica carlos chagas filho
instituto de pesquisa e ensino d'or - IDOR
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients; 18 years of age and older; admitted to the ICU with COVID-19 confirmed via positive RT-PCR or CT scan suggestive of pneumonia caused by COVID-19
Exclusion criteria
Exclusion criteria: Estimated length of hospital stay less than 3 days; Patients who progressed to orotracheal intubation in less than 48 hours of hospital stay; Patients whose non-invasive ventilatory therapy has lasted less than 48 hours; Patients whose medical records lack predictive and outcome variables
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of tracheal intubation in patients who used non-invasive ventilation, high flow nasal cannula or both during hospital stay | — |
Secondary
| Measure | Time frame |
|---|---|
| Identify the use or not of oxygen (unnecessary, up to 1 LO2/min, from 1 to 5 LO2/min and greater than 5 LO2/min) of patients submitted to different non-invasive ventilation devices. ;Describe the types of non-invasive support interface [helmet, full face, oronasal and high flow nasal catheter], as well as the ventilation parameters used. ;Observe whether there is an association of worse clinical outcomes in non-invasive ventilation and/or higt flow nasal cannula according to the degree of pulmonary involvement through chest computed tomography (less than 25%; between 25 and 50% and greater than 50% of the affected area) at the time of hospital admission.;Compare patients who used non-invasive ventilation under high tidal volumes with those who underwent the same therapy under low tidal volumes (or airway pressure levels, which indirectly will be related to different tidal volume needs), as well as in time the use of non-inasive ventilation in order to seek inferences about vigorous muscular efforts and worse clinical outcomes. ;Identify clinical outcomes related to the incidence of orotracheal intubation (failure of non-invasive ventilatory support), as well as the time to orotracheal intubation, length of stay in the intensive care unit and hospital, and in-hospital mortality. ;Identify patients who progressed to hemodialysis therapy during the course of the study as a way of inferring distal damage.;Identify whether the concomitant use of some drugs, such as corticosteroids and anticoagulants, could be related to clinical outcomes. | — |
Countries
Brazil
Contacts
Public ContactAmanda da Cruz
instituto de biofisica carlos chagas filho
Outcome results
None listed