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Creatine supplementation plus resistance training in adults

Effect of Creatine Monohydrate Supplementation in association with Strength Training with Blood Flow Restriction on strength and muscle mass gain in untrained men

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-3vh8zgj
Enrollment
Unknown
Registered
2022-10-14
Start date
2019-07-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedentary

Interventions

Seventeen healthy, non-vegetarian, non-vegan, untrained, male undergraduate students from the Federal University of Maranhão were recruited for this study. Nine volunteers participated in the placebo

Sponsors

Universidade Federal do Maranhão
Lead Sponsor
Universidade Federal do Maranhão
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Male participants between eighteen and thirty years of age

Exclusion criteria

Exclusion criteria: Volunteers who have a body mass index below eighteen and above twenty-four; or those who, of their own free will, no longer want to participate in the study; do not attend training and collection sites on scheduled days; Have participated in strength training in the past six months; having used a food supplement or ergogenic medication for at least two years before the study; smoking or drinking alcohol at least a week before tests

Design outcomes

Primary

MeasureTime frame
Expected Outcome 1: It was expected to find that creatine supplementation could increase muscle performance and improve muscle adaptations to the BFR paradigm. It was further expected that when evaluated for a single set performed to concentric failure at 30% of 1RM, the maximum number of repetitions performed in the BFR creatine group would be significantly greater than the BFR placebo or TRAD groups at 8 weeks;Outcome Found 1: Through the method used (BFR) and creatine supplementation, these findings are in agreement with our initial hypothesis that increased phosphocreatine stores may be related to increased work capacity in the BFR paradigm, which also may be related to increased muscle hypertrophy response. It was observed for the first time that 8 weeks of creatine supplementation during training with BFR increased training volume load (VLT) compared to placebo with BFR. On some variables, such as repetitions to failure at 30% 1RM, the BFR creatine-supplemented group performed better than the BFR placebo, TRAD placebo, and the TRAD creatine-supplemented group. Regarding muscle thickness response, creatine supplementation promoted additional increases in muscle thickness in both the TRAD and BFR paradigms compared to their placebo counterparts. It was observed that 8 weeks of TRAD increased biceps muscle thickness by 9.5% (versus pre-exercise condition), which is similar to previous literature data, compared to the BFR-PL model = 9.1%. Creatine supplementation resulted in a 17% increase in muscle thickness after 8 weeks, indicating the effectiveness of creatine when associated with the TRAD paradigm for hypertrophy purposes, as well as increases in muscle thickness (BFR-CR = 12.7%). when associated with the BFR model. Therefore, it was observed that creatine supplementation can be considered anabolic for BFR and TRAD, and ergogenic for BFR in our experimental settings

Secondary

MeasureTime frame
Expected Outcome 2: Increases in total body mass and changes in body composition were expected, especially in groups involving creatine supplementation;Outcome Found 2: An increase of ~1.4 kg in total body mass and lean body mass was observed in the creatine groups between baseline (pre) and week 2. These findings are comparable to other studies in the literature that reported increases in body mass and total body water

Countries

Brazil

Contacts

Public ContactNelo Zanchi

Universidade Federal do Maranhão

nelonzpt@gmail.com+55-098-32729064

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026